European Heart Journal Advance Access published online on August 7, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl181
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1 Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School 1715 Kamakari, Imba, Chiba 270-1694, Japan
* To whom correspondence should be addressed. Aims The neointimal coverage and intracoronary thrombi within stented segments at 6 months after implantation between sirolimus-eluting stents (SESs) and bare metal stents (BMSs) were compared by direct visualization using angioscopy. Methods and results Forty-six patients (36 stable angina and 10 acute coronary syndrome) were treated with 33 SESs and 33 BMSs. Immediately after and 6 months after stenting, each of the stented segments, edge body, and overlapping segment were observed by angioscopy and the grade of neointimal coverage over the stents was classified as 0: absent neointima, 1: visible struts through thin neointima, or 2: invisible struts. The existence of thrombi was also evaluated. The average grade of the neointimal coverage at 6 months follow-up was lower in the SES than that in the BMS (edge: 1.4 ± 0.7 vs. 1.9 ± 0.2, body: 1.0 ± 0.5 vs. 1.8 ± 0.5, overlapping segment: 0.6 ± 0.7 vs. 1.8 ± 0.5; P < 0.0001, P < 0.0001, P = 0.0069, respectively). The frequency of persistence of thrombus was significantly higher in the SESs than that in the BMSs (86 vs. 29%, respectively; P = 0.031). Conclusion The present study suggested a delayed neointimal stent coverage and slower thrombus disappearance process in the SESs in comparison to the BMSs.
Received February 18, 2006
Revised June 15, 2006
Accepted July 14, 2006
Clinical research
Angioscopic differences in neointimal coverage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation
Masamichi Takano 1, Takayoshi Ohba 1, Shigenobu Inami 1, Koji Seimiya 1, Shunta Sakai 1, and Kyoichi Mizuno 1 *
Kyoichi Mizuno, E-mail: mizunok{at}nms.ac.jp
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