Skip Navigation



European Heart Journal Advance Access published online on August 21, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl192
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/18/2165    most recent
ehl192v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bigalke, B.
Right arrow Articles by Gawaz, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bigalke, B.
Right arrow Articles by Gawaz, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received March 4, 2006
Revised June 23, 2006
Accepted July 27, 2006

Preclinical research

Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome

Boris Bigalke 1, Stephan Lindemann 1 *, Raila Ehlers 1, Peter Seizer 1, Karin Daub 1, Harald Langer 1, Tanja Schonberger 1, Elisabeth Kremmer 2, Dorothea Siegel-Axel 1, Andreas E. May 1, and Meinrad Gawaz 1 *

1 Medizinische Klinik III, Eberhard Karls-Universität Tübingen, Otfried-Müller-Str. 10, D-72076 Tübingen, Germany
2 Institute for Molecular Immunology, GSF-National Research Center for Environment and Health, Munich, Germany

* To whom correspondence should be addressed.
Stephan Lindemann, E-mail: stephan.lindemann{at}med.uni-tuebingen.de
Meinrad Gawaz, E-mail: meinrad.gawaz{at}med.uni-tuebingen.de


  Abstract

Aims Platelet collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis. In this observational study, we examined the platelet surface expression of GPVI in patients with symptomatic coronary artery disease (CAD).

Methods and results We evaluated a consecutive cohort of 367 patients with symptomatic CAD, who underwent coronary angiography. The surface expression of platelet activation markers (GPVI, CD62P, and CD42b) was determined by flow cytometry. Patients with acute coronary syndrome (ACS) showed a significantly enhanced GPVI expression on admission when compared with patients with stable angina pectoris (SAP) (ACS: 21.4 ± 9.7; SAP: 18.6 ± 7.1 mean fluorescence intensity ± SD; P = 0.004). The expression of GPVI correlated with CD62P (r = 0.702; P = 0.001). Logistic regression analysis demonstrated that on admission, elevated platelet GPVI expression was associated with ACS, independent of markers of myocardial necrosis such as troponin and creatine kinase.

Conclusion Platelet GPVI surface expression is elevated in patients with ACS and is associated with imminent acute coronary events. The determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischaemia is evident.

Keywords: Platelets; Glycoprotein VI; Collagen; Acute coronary syndrome.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
E. E. Gardiner, D. Karunakaran, J. F. Arthur, F.-T. Mu, M. S. Powell, R. I. Baker, P. M. Hogarth, M. L. Kahn, R. K. Andrews, and M. C. Berndt
Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing Fc{gamma}RIIa
Blood, January 1, 2008; 111(1): 165 - 174.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. P. Giugliano and E. Braunwald
The Year in Non ST-Segment Elevation Acute Coronary Syndrome
J. Am. Coll. Cardiol., October 2, 2007; 50(14): 1386 - 1395.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. K. Andrews, D. Karunakaran, E. E. Gardiner, and M. C. Berndt
Platelet Receptor Proteolysis: A Mechanism for Downregulating Platelet Reactivity
Arterioscler. Thromb. Vasc. Biol., July 1, 2007; 27(7): 1511 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Grothusen, S. Umbreen, I. Konrad, K. Stellos, C. Schulz, B. Schmidt, E. Kremmer, O. Teebken, S. Massberg, M. Luchtefeld, et al.
EXP3179 Inhibits Collagen-Dependent Platelet Activation via Glycoprotein Receptor-VI Independent of AT1-Receptor Antagonism: Potential Impact on Atherothrombosis
Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1184 - 1190.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
F. F. Samaha and M. L. Kahn
Novel Platelet and Vascular Roles for Immunoreceptor Signaling
Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2588 - 2593.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.