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European Heart Journal Advance Access published online on October 14, 2007
European Heart Journal, doi:10.1093/eurheartj/ehl195
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Drug-eluting stents: effective and safe for every patient and every lesion?

Uwe Zeymer1,* and Ralf Zahn2

1 Herzzentrum Ludwigshafen, Department of Cardiology, Medizinische Klinik B, Bremserstrasse 79, D-67063 Ludwigshafen, Germany
2 Klinikum Nürnberg-Süd, Medizinische Klinik 8, Germany

* Corresponding author. Tel: +49621 503 4045; fax: +49621 503 4002. E-mail address: uwe.zeymer@t-online.de

This editorial refers to ‘TAXUS VI 2 year follow up: Randomized comparison of polymer-based paclitaxel-eluting with bare metal stents for treatment of long, complex lesions’ by E. Grube et al., doi:10.1093/eurheartj/ehm424

The first 10% of the full text of this article appears below.

When Andreas Grüntzig performed the first percutaneous transluminal coronary angioplasty in 1978, he did not expect that this procedure would become one of the most often performed interventions in medicine worldwide. The Achilles' heels of balloon angioplasty were early reocclusions and restenosis. However, >60% of the patients after plain old balloon angioplasty did well without any need for repeat target lesion revascularizations. With the introduction of stents, the procedure became more predictable with respect to early reocclusions and the rate of clinically driven repeat revascularization procedures declined to ~20%, depending on lesion characteristics such as vessel diameter and lesion length and concomitant diseases such as diabetes mellitus and renal insufficiency. However, in randomized clinical trials, no benefit in death and re-infarction was . . . [Full Text of this Article]

Benefit of drug-eluting stents

Problems of the randomized DES trials

DES in long, complex lesions

Pending problems with DES

Future developments

Summary


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