European Heart Journal Advance Access published online on August 25, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl206
1 Cardiovascular Department, AP-HP, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France
* To whom correspondence should be addressed. Aims Management of patients with mitral stenosis (MS) relies on accurate evaluation of the mitral valve area (MVA). Planimetry (MVA2D) is considered as the reference method but must be performed at the tips of the leaflets with the correct plane orientation and therefore requires experienced operators. Real-time three-dimensional echocardiography (RT3DE) may overcome this limitation but its usefulness for experienced when compared with less experienced operators has not been evaluated. In addition, superiority of RT3DE for the evaluation of commissural splitting after percutaneous mitral commissurotomy (PMC) is unknown. Methods and results 60 patients were prospectively evaluated by 2D and RT3DE before and after PMC by experienced operators. Before PMC, MVA3D was slightly higher than MVA2D (1.15 ± 0.25 vs. 1.06 ± 0.22 cm2, P = 0.0001) but correlation between methods was excellent (r = 0.73, P < 0.0001), mean difference was small (0.09 ± 0.18 cm2) and clinically meaningless (three patients misclassified, two of whom had borderline MS severity). After PMC, MVA3D did not differ from and correlated well with MVA2D (1.87 ± 0.37 vs. 1.85 ± 0.32 cm2, P = 0.36; r = 0.76, P < 0.0001; mean difference 0.03 ± 0.24 cm2). Twenty-five additional patients were also evaluated both by an experienced and a less experienced operators. Bland-Altman analysis showed the better agreement between MVA3D measured by the less experienced operator and MVA2D measured by the experienced operator than between MVA2D measured by the less experienced and the experienced operators (mean difference 0.03 ± 0.34 vs. - 0.13 ± 0.46 cm2, P = 0.03). When compared with RT3DE, 2DE underestimated the degree of commissural opening in 33% of patients and agreement between methods was weak ( Conclusion RT3DE provides accurate MVA measurements similar to 2D planimetry performed by experienced operators. Thus, it does not provide a real advantage for experienced operators, whereas it seems particularly helpful for less experienced operators. In addition, RT3DE improves the description of valvular anatomy.
Received December 6, 2005
Revised August 7, 2006
Accepted August 10, 2006
Clinical research
Three-dimensional evaluation of the mitral valve area and commissural opening before and after percutaneous mitral commissurotomy in patients with mitral stenosis
David Messika-Zeitoun 1 *, Eric Brochet 1, Caroline Holmin 1, David Rosenbaum 1, Bertrand Cormier 1, Jean-Michel Serfaty 2, Bernard Iung 1, and Alec Vahanian 1
2 Radiology Department, AP-HP, Bichat Hospital, Paris, France
David Messika-Zeitoun, E-mail: david.messika-zeitoun{at}bch.ap-hop-paris.fr
Abstract 
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