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European Heart Journal Advance Access published online on September 19, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl207
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European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received April 25, 2006
Revised August 8, 2006
Accepted August 10, 2006

Clinical research

The relationship between coronary artery disease and abnormal glucose regulation in China: the China Heart Survey

Da-Yi Hu 1 *, Chang-Yu Pan 2, and Jin-Ming Yu 1, for the China Heart Survey Group

1 Centre for Cardiovascular and Pulmonary Blood Vessels, Tongji University, Shanghai, China
2 Department of Endocrinology, General Hospital of the Chinese People's Liberation Army, Beijing, China

* To whom correspondence should be addressed.
Da-Yi Hu, E-mail: heart{at}gw-icc.org


  Abstract

Aim The aim of this article is to characterize the glucometabolic state of patients with coronary artery disease (CAD) in China.

Methods and results This multicentre study recruited 3513 patients hospitalized for CAD, of whom 35.1% were admissions for acute CAD and 64.9% were elective admissions for CAD. At entry, 1153 patients had known type 2 diabetes and 97 had newly diagnosed diabetes [fasting plasma glucose level (FPG)  ≥ 7.0 mmol/L]. Oral glucose tolerance tests (OGTTs) performed in the remaining patients revealed that 26.9% had diabetes and 37.3% had impaired glucose regulation (IGR). The prevalence of abnormal glucose regulation (AGR) was similar in the acute and elective admissions groups. Overall, the proportion of patients with diagnosed diabetes increased from 32.8% at baseline to 52.9% post-OGTT analysis. In total, 87.4% of patients with IGR and 80.5% of patients with diabetes would have remained undiagnosed if OGTTs had not been performed.

Conclusion AGR is common in patients with CAD. The prevalence of AGR is underestimated by FPG testing alone. OGTTs should be routinely used to assess the glucometabolic state of patients with CAD. Individuals identified with IGR or type 2 diabetes should receive treatment to reduce the progression of AGR and associated complications.

Keywords: China Heart Survey; Coronary artery disease; Impaired glucose regulation; Oral glucose tolerance test; Type 2 diabetes.
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