Skip Navigation



European Heart Journal Advance Access published online on September 25, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl271
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/20/2413    most recent
ehl271v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ishihara, M.
Right arrow Articles by Kagawa, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ishihara, M.
Right arrow Articles by Kagawa, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received February 28, 2006
Revised September 4, 2006
Accepted September 11, 2006

Clinical research

Is admission hyperglycaemia in non-diabetic patients with acute myocardial infarction a surrogate for previously undiagnosed abnormal glucose tolerance?

Masaharu Ishihara 1 *, Ichiro Inoue 1, Takuji Kawagoe 1, Yuji Shimatani 1, Satoshi Kurisu 1, Takaki Hata 1, Yasuharu Nakama 1, Yasufumi Kijima 1, and Eisuke Kagawa 1

1 Department of Cardiology, Hiroshima City Hospital, 7-33, Moto-machi, Naka-ku, Hiroshima 730-8518, Japan

* To whom correspondence should be addressed.
Masaharu Ishihara, E-mail: ishifami{at}fb3.so-net.ne.jp


  Abstract

Aims To investigate whether admission hyperglycaemia in non-diabetic patients with acute myocardial infarction (AMI) is a surrogate for previously undiagnosed abnormal glucose tolerance.

Methods and results Two hundred non-diabetic patients with AMI were divided into three groups: 81 patients with admission glucose <7.8 mmol/L (group 1), 83 patients with admission glucose ≥7.8 mmol/L and <11.1 mmol/L (group 2), and 36 patients with admission glucose ≥11.1 mmol/L (group 3). Abnormal glucose tolerance, diabetes, or impaired glucose tolerance (IGT) was diagnosed by oral glucose tolerance test (OGTT). OGTT identified diabetes in 53 patients (27%) and IGT in 78 patients (39%). When the fasting glucose criteria were applied, however, only 14 patients (7%) were diagnosed as having diabetes. The prevalence of abnormal glucose tolerance was similar among the three groups: 67% in group 1, 63% in group 2, and 69% in group 3 (P = 0.74). The relation of fasting glucose (r2 = 0.50, P < 0.001) and HbA1c (r2 = 0.34, P < 0.001) to 2-h post-load glucose was significant, but the relation of admission glucose to 2-h post-load glucose was not significant (r2 = 0.02, P = 0.08). Multivariable analysis showed that fasting glucose and HbA1c were independent predictors of abnormal glucose tolerance, but admission glucose was not.

Conclusion Admission hyperglycaemia in non-diabetic patients with AMI does not represent previously undiagnosed abnormal glucose tolerance. Fasting glucose and HbA1c, rather than admission glucose, may be useful to predict abnormal glucose tolerance. However, these parameters lacked sensitivity. OGTT should be considered in all non-diabetic patients with AMI.

Keywords: Glucose; Diabetes; Myocardial infarction.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll Cardiol ImgHome page
D. E. Hofsten, B. B. Logstrup, J. E. Moller, P. A. Pellikka, and K. Egstrup
Abnormal glucose metabolism in acute myocardial infarction influence on left ventricular function and prognosis.
J. Am. Coll. Cardiol. Img., May 1, 2009; 2(5): 592 - 599.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
R Anantharaman, M Heatley, and C F M Weston
Hyperglycaemia in acute coronary syndromes: risk-marker or therapeutic target?
Heart, May 1, 2009; 95(9): 697 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
O. E. Okosieme, R. Peter, M. Usman, H. Bolusani, P. Suruliram, L. George, and L. M. Evans
Can Admission and Fasting Glucose Reliably Identify Undiagnosed Diabetes in Patients With Acute Coronary Syndrome?
Diabetes Care, October 1, 2008; 31(10): 1955 - 1959.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
C Weston, L Walker, J Birkhead, and National Audit of Myocardial Infarction Project, N
Early impact of insulin treatment on mortality for hyperglycaemic patients without known diabetes who present with an acute coronary syndrome
Heart, December 1, 2007; 93(12): 1542 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
K. P. Goran
The consensus is clearly needed for the definition of stress hyperglycaemia in acute myocardial infarction
Eur. Heart J., August 2, 2007; 28(16): 2042 - 2042.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. Verges, M. Zeller, G. Dentan, J.-C. Beer, Y. Laurent, L. Janin-Manificat, H. Makki, J. E. Wolf, Y. Cottin, and on behalf of the Observatoire des Infarctus de Cot
Impact of Fasting Glycemia on Short-Term Prognosis after Acute Myocardial Infarction
J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2136 - 2140.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.