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European Heart Journal Advance Access published online on October 6, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl305
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European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received March 28, 2006
Revised September 14, 2006
Accepted September 21, 2006

Review

Platelets and heart failure

Irene Chung 1 and Gregory YH Lip 1 *

1 Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK

* To whom correspondence should be addressed.
Gregory YH Lip, E-mail: g.y.h.lip{at}bham.ac.uk


  Abstract

Heart failure is associated with increased risk of venous thromboembolism, stroke, and sudden death. Platelet abnormalities have been well described in heart failure but the significance of platelets in contributing to the thromboembolic complications of heart failure remains uncertain. Furthermore, the role of antiplatelet agents in heart failure remains unclear. This review will focus on platelet activation and the role of platelet dysfunction in heart failure, with particular regard to pathophysiology and outcome. The effects of heart failure therapeutics on platelet function and antiplatelet therapy in heart failure will also be discussed.

Keywords: Platelet activation; Heart failure; CD40L; P-selectin; Antiplatelet therapy.
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