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European Heart Journal Advance Access published online on January 24, 2007
European Heart Journal, doi:10.1093/eurheartj/ehl462
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Inflammatory and coagulative markers of atherosclerosis

Edoardo Casiglia* and Valérie Tikhonoff

Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani, 2 I-35126 Padova, Italy

* Corresponding author. Tel: +39 049 8212277; fax: +39 049 8754179. E-mail address: edoardo.casiglia@unipd.it

This editorial refers to ‘Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study’ by L. Jørgensen et al., doi:10.1093/eurheartj/ehl394 and ‘Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study’ by I. Tzoulaki et al., doi:10.1093/eurheartj/ehl441

The first 10% of the full text of this article appears below.

Many markers associated with atherosclerosis have been identified in the last 50 years. Some of them act as factors, both mathematically (factors = risk multipliers) and biologically (factors from the latin facient, producing), and others are mere indicators. Among the novel markers (Table 1), many are strictly connected with inflammation or coagulation. Some studies on these markers have been considered with suspect, because they were conducted on patients rather than on general population, because the number of subjects was low, or because the experimental design was inadequate. Nevertheless, the results of all studies are univocal and similar to those of population-based large-scale studies.1–5 Today there is, therefore, general agreement on the role of these novel markers. Although incertitude remains about the underlying pathophysiological mechanism, inflammation . . . [Full Text of this Article]


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Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study
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EHJ 2007 28: 363-369. [Abstract] [FREE Full Text]