European Heart Journal Advance Access published online on March 15, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm013
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Changes in haemoglobin levels during hospital course and long-term outcome after acute myocardial infarction
Department of Cardiology, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion, PO Box 9602, Haifa 31096, Israel
Received 14 August 2006; revised 5 February 2007; accepted 15 February 2007.
* Corresponding author. Tel: +972-48-542790; fax: +972-48-542176. E-mail address: daronson{at}techunix.technion.ac.il
Aims: To study the prevalence and long-term prognostic significance of changes in haemoglobin levels during hospital course in survivors of acute myocardial infarction (AMI).
Methods and results: A prospective study involving 1390 patients who were admitted with AMI. Median follow-up was 24 months. Multivariable Cox models were used to evaluate the relationship between nadir and discharge haemoglobin and mortality after hospital discharge. Anaemia was present in 248 patients on admission (17.8%) and in 502 patients at discharge (36.1%). Nadir haemoglobin during hospital course was 1.3 g/dL lower (IQR 0.6–2.2) when compared with baseline haemoglobin (P < 0.0001). Low nadir haemoglobin and discharge haemoglobin were strongly associated with increased mortality. After adjusting for clinical variables and ejection fraction, the hazard ratios for a 1 g/dL decrease in nadir haemoglobin and discharge haemoglobin were 1.36 (95% CI 1.19–1.55; P < 0.0001) and 1.27 (95% CI 1.16–1.40; P < 0.0001), respectively.
Conclusion: The development of anaemia during hospitalization for AMI is frequent and is associated with an increased long-term mortality.
Key Words: Anaemia • Heart failure • Myocardial infarction • Prognosis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. D. Anker, A. Voors, D. Okonko, A. L. Clark, M. K. James, S. von Haehling, J. Kjekshus, P. Ponikowski, K. Dickstein, and for the OPTIMAAL Investigators Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial Eur. Heart J., June 1, 2009; 30(11): 1331 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cheng, D. A. Morrow, S. Sloan, E. M. Antman, and M. S. Sabatine Predictors of Initial Nontherapeutic Anticoagulation With Unfractionated Heparin in ST-Segment Elevation Myocardial Infarction Circulation, March 10, 2009; 119(9): 1195 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Liron Nosocomial anaemia Eur. Heart J., October 2, 2007; 28(20): 2551 - 2551. [Full Text] [PDF]
|
|
|
|
|
|
D. Aronson, W. Markiewicz, and H. Hammerman Nosocomial anaemia: reply Eur. Heart J., October 2, 2007; 28(20): 2551 - 2552. [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Bassand Impact of anaemia, bleeding, and transfusions in acute coronary syndromes: a shift in the paradigm Eur. Heart J., June 1, 2007; 28(11): 1273 - 1274. [Full Text] [PDF]
|
|