Skip Navigation



European Heart Journal Advance Access published online on April 11, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm037
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
28/20/2539    most recent
ehm037v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Paulus, W. J.
Right arrow Articles by Brutsaert, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paulus, W. J.
Right arrow Articles by Brutsaert, D. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology

Walter J. Paulus1,*, Carsten Tschöpe2, John E. Sanderson3, Cesare Rusconi4, Frank A. Flachskampf5, Frank E. Rademakers6, Paolo Marino7, Otto A. Smiseth8, Gilles De Keulenaer9, Adelino F. Leite-Moreira10, Attila Borbély11, István Édes11, Martin Louis Handoko1, Stephane Heymans12, Natalia Pezzali4, Burkert Pieske13, Kenneth Dickstein14, Alan G. Fraser15 and Dirk L. Brutsaert9

1 Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
2 Charité Universitätskliniken, Campus Benjamin Franklin, Berlin, Germany
3 Keele University, Stoke-on-Trent, UK
4 S.Orsola Hospital, Brescia, Italy
5 University of Erlangen, Germany
6 University of Leuven, Belgium
7 Universita degli Studi del Piemonte Orientale, Novara, Italy
8 Rikshospitalet, Oslo, Norway
9 Middelheim Ziekenhuis, Antwerp, Belgium
10 University of Porto, Portugal
11 Institute of Cardiology UDMHSC, Debrecen, Hungary
12 University Hospital Maastricht, The Netherlands
13 Georg-August-Universität, Göttingen, Germany
14 Stavanger University Hospital, Norway
15 University of Wales College of Medicine, Cardiff, UK

Received 28 November 2006; accepted 23 February 2007.

* Corresponding author. Tel: +31 20 4448110; fax: +31 20 4448255. E-mail address: wj.paulus{at}vumc.nl

Diastolic heart failure (DHF) currently accounts for more than 50% of all heart failure patients. DHF is also referred to as heart failure with normal left ventricular (LV) ejection fraction (HFNEF) to indicate that HFNEF could be a precursor of heart failure with reduced LVEF. Because of improved cardiac imaging and because of widespread clinical use of plasma levels of natriuretic peptides, diagnostic criteria for HFNEF needed to be updated. The diagnosis of HFNEF requires the following conditions to be satisfied: (i) signs or symptoms of heart failure; (ii) normal or mildly abnormal systolic LV function; (iii) evidence of diastolic LV dysfunction. Normal or mildly abnormal systolic LV function implies both an LVEF > 50% and an LV end-diastolic volume index (LVEDVI) <97 mL/m2. Diagnostic evidence of diastolic LV dysfunction can be obtained invasively (LV end-diastolic pressure >16 mmHg or mean pulmonary capillary wedge pressure >12 mmHg) or non-invasively by tissue Doppler (TD) (E/E' > 15). If TD yields an E/E' ratio suggestive of diastolic LV dysfunction (15 > E/E' > 8), additional non-invasive investigations are required for diagnostic evidence of diastolic LV dysfunction. These can consist of blood flow Doppler of mitral valve or pulmonary veins, echo measures of LV mass index or left atrial volume index, electrocardiographic evidence of atrial fibrillation, or plasma levels of natriuretic peptides. If plasma levels of natriuretic peptides are elevated, diagnostic evidence of diastolic LV dysfunction also requires additional non-invasive investigations such as TD, blood flow Doppler of mitral valve or pulmonary veins, echo measures of LV mass index or left atrial volume index, or electrocardiographic evidence of atrial fibrillation. A similar strategy with focus on a high negative predictive value of successive investigations is proposed for the exclusion of HFNEF in patients with breathlessness and no signs of congestion.

The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF.

Key Words: Heart failure • Diastole • Tissue doppler • Natriuretic peptides • Ejection fraction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Basu, G. Y. Oudit, X. Wang, L. Zhang, J. R. Ussher, G. D. Lopaschuk, and Z. Kassiri
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2096 - H2108.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
W Oliveira, O Campos, F Cintra, L Matos, M L C Vieira, B Rollim, L Fujita, S Tufik, and D Poyares
Impact of continuous positive airway pressure treatment on left atrial volume and function in patients with obstructive sleep apnoea assessed by real-time three-dimensional echocardiography
Heart, November 15, 2009; 95(22): 1872 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
N. S. Chahal, T. K. Lim, P. Jain, J. C. Chambers, J. S. Kooner, and R. Senior
Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study
Eur J Echocardiogr, November 12, 2009; (2009) jep164v1.
[Abstract] [Full Text] [PDF]

Home page
 Circ Heart FailHome page
M. Guazzi, K. Dickstein, M. Vicenzi, and R. Arena
Six-Minute Walk Test and Cardiopulmonary Exercise Testing in Patients With Chronic Heart Failure: A Comparative Analysis on Clinical and Prognostic Insights
Circ Heart Fail, November 1, 2009; 2(6): 549 - 555.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
F. Zannad, N. Agrinier, and F. Alla
Heart failure burden and therapy
Europace, November 1, 2009; 11(suppl_5): v1 - v9.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J.-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
Eur. Heart J., October 2, 2009; 30(20): 2493 - 2537.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
Endorsed by the European Society of Clinical Micro, Authors/Task Force Members, G. Habib, B. Hoen, P. Tornos, F. Thuny, B. Prendergast, I. Vilacosta, P. Moreillon, M. de Jesus Antunes, et al.
Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC)
Eur. Heart J., October 1, 2009; 30(19): 2369 - 2413.
[Full Text] [PDF]

Home page
 HeartHome page
G. W.-K. Yip, M. Frenneaux, and J. E Sanderson
Heart failure with a normal ejection fraction: new developments
Heart, October 1, 2009; 95(19): 1549 - 1552.
[Full Text] [PDF]

Home page
 CirculationHome page
W. C. Little and J. K. Oh
Echocardiographic Evaluation of Diastolic Function Can Be Used to Guide Clinical Care
Circulation, September 1, 2009; 120(9): 802 - 809.
[Full Text] [PDF]

Home page
 CirculationHome page
C. Tschope and W. J. Paulus
Doppler Echocardiography Yields Dubious Estimates of Left Ventricular Diastolic Pressures
Circulation, September 1, 2009; 120(9): 810 - 820.
[Full Text] [PDF]

Home page
 HypertensionHome page
R. M. Wilson, D. S. De Silva, K. Sato, Y. Izumiya, and F. Sam
Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure
Hypertension, September 1, 2009; 54(3): 583 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
N. Hamdani, W. J. Paulus, L. van Heerebeek, A. Borbely, N. M. Boontje, M. J. Zuidwijk, J. G.F. Bronzwaer, W. S. Simonides, H. W. M. Niessen, G. J. M. Stienen, et al.
Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction
Eur. Heart J., August 1, 2009; 30(15): 1863 - 1872.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
E. Aune, M. Baekkevar, J. Roislien, O. Rodevand, and J. E. Otterstad
Normal reference ranges for left and right atrial volume indexes and ejection fractions obtained with real-time three-dimensional echocardiography
Eur J Echocardiogr, August 1, 2009; 10(6): 738 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
S. C. Govind, A. S. Gopal, A. Netyo, J. Nowak, L.-A. Brodin, A. Patrianakos, S.S. Ramesh, and S. Saha
Quantification of low-dose dobutamine stress using speckle tracking echocardiography in coronary artery disease
Eur J Echocardiogr, July 1, 2009; 10(5): 607 - 612.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. H. Marwick
The deconvolution of diastole.
J. Am. Coll. Cardiol., June 30, 2009; 54(1): 47 - 48.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. M. Hoeper, J. A. Barbera, R. N. Channick, P. M. Hassoun, I. M. Lang, A. Manes, F. J. Martinez, R. Naeije, H. Olschewski, J. Pepke-Zaba, et al.
Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S85 - S96.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
A. T. Burns, A. La Gerche, D. L. Prior, and A. I. MacIsaac
Left Ventricular Untwisting Is an Important Determinant of Early Diastolic Function
J. Am. Coll. Cardiol. Img., June 1, 2009; 2(6): 709 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
T. Bitter, L. Faber, D. Hering, C. Langer, D. Horstkotte, and O. Oldenburg
Sleep-disordered breathing in heart failure with normal left ventricular ejection fraction
Eur J Heart Fail, June 1, 2009; 11(6): 602 - 608.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Opdahl, E. W. Remme, T. Helle-Valle, E. Lyseggen, T. Vartdal, E. Pettersen, T. Edvardsen, and O. A. Smiseth
Determinants of Left Ventricular Early-Diastolic Lengthening Velocity: Independent Contributions From Left Ventricular Relaxation, Restoring Forces, and Lengthening Load
Circulation, May 19, 2009; 119(19): 2578 - 2586.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
J. R. Dalzell and C. E. Jackson
Diastolic heart failure
Can. Med. Assoc. J., April 28, 2009; 180(9): 952 - 952.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. S.P. Lam, V. L. Roger, R. J. Rodeheffer, B. A. Borlaug, F. T. Enders, and M. M. Redfield
Pulmonary hypertension in heart failure with preserved ejection fraction a community-based study.
J. Am. Coll. Cardiol., March 31, 2009; 53(13): 1119 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Borbely, I. Falcao-Pires, L. van Heerebeek, N. Hamdani, I. Edes, C. Gavina, A. F. Leite-Moreira, J. G.F. Bronzwaer, Z. Papp, J. van der Velden, et al.
Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium
Circ. Res., March 27, 2009; 104(6): 780 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. T. Maeder and D. M. Kaye
Heart failure with normal left ventricular ejection fraction.
J. Am. Coll. Cardiol., March 17, 2009; 53(11): 905 - 918.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Wang and S. F. Nagueh
Current Perspectives on Cardiac Function in Patients With Diastolic Heart Failure
Circulation, March 3, 2009; 119(8): 1146 - 1157.
[Full Text] [PDF]

Home page
 Circ Heart FailHome page
T. Kuznetsova, L. Herbots, B. Lopez, Y. Jin, T. Richart, L. Thijs, A. Gonzalez, M.-C. Herregods, R. H. Fagard, J. Diez, et al.
Prevalence of Left Ventricular Diastolic Dysfunction in a General Population
Circ Heart Fail, March 1, 2009; 2(2): 105 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. B. Srichai, R. P. Lim, S. Wong, and V. S. Lee
Cardiovascular Applications of Phase-Contrast MRI
Am. J. Roentgenol., March 1, 2009; 192(3): 662 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
S. F. Nagueh, C. P. Appleton, T. C. Gillebert, P. N. Marino, J. K. Oh, O. A. Smiseth, A. D. Waggoner, F. A. Flachskampf, P. A. Pellikka, and A. Evangelisa
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Eur J Echocardiogr, March 1, 2009; 10(2): 165 - 193.
[Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A. A. Alsaddique, A. G. Royse, C. F. Royse, and M. A. Fouda
Management of diastolic heart failure following cardiac surgery
Eur. J. Cardiothorac. Surg., February 1, 2009; 35(2): 241 - 249.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. Grassi, G. Seravalle, F. Quarti-Trevano, R. Dell'Oro, F. Arenare, D. Spaziani, and G. Mancia
Sympathetic and Baroreflex Cardiovascular Control in Hypertension-Related Left Ventricular Dysfunction
Hypertension, February 1, 2009; 53(2): 205 - 209.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. E Sanderson and G. W K Yip
Heart failure with a normal ejection fraction
BMJ, January 27, 2009; 338(jan27_1): b52 - b52.
[Full Text]

Home page
 CirculationHome page
W. Mullens, A. G. Borowski, R. J. Curtin, J. D. Thomas, and W.H. Tang
Tissue Doppler Imaging in the Estimation of Intracardiac Filling Pressure in Decompensated Patients With Advanced Systolic Heart Failure
Circulation, January 6, 2009; 119(1): 62 - 70.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. D. Solomon and L. W. Stevenson
Recalibrating the Barometer: Is It Time to Take a Critical Look at Noninvasive Approaches to Measuring Filling Pressures?
Circulation, January 6, 2009; 119(1): 13 - 15.
[Full Text] [PDF]

Home page
 Circ Cardiovasc ImagingHome page
M. Kurt, J. Wang, G. Torre-Amione, and S. F. Nagueh
Left Atrial Function in Diastolic Heart Failure
Circ Cardiovasc Imaging, January 1, 2009; 2(1): 10 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
L. van Heerebeek and W. J. Paulus
The dialogue between diabetes and diastole
Eur J Heart Fail, January 1, 2009; 11(1): 3 - 5.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
C. Jarnert, L. Landstedt-Hallin, K. Malmberg, A. Melcher, J. Ohrvik, H. Persson, and L. Ryden
A randomized trial of the impact of strict glycaemic control on myocardial diastolic function and perfusion reserve: a report from the DADD (Diabetes mellitus And Diastolic Dysfunction) study
Eur J Heart Fail, January 1, 2009; 11(1): 39 - 47.
[Abstract] [Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
F. A. Flachskampf, J.-U. Voigt, and W. G. Daniel
CHAPTER 4 Cardiac Ultrasound
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
J. McMurray, M. Petrie, K. Swedberg, M. Komajda, S. Anker, and R. Gardner
CHAPTER 23 Heart Failure
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
N. Galiè and A. Manes
CHAPTER 24 Pulmonary Hypertension
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
B. M. Massie, P. E. Carson, J. J. McMurray, M. Komajda, R. McKelvie, M. R. Zile, S. Anderson, M. Donovan, E. Iverson, C. Staiger, et al.
Irbesartan in Patients with Heart Failure and Preserved Ejection Fraction
N. Engl. J. Med., December 4, 2008; 359(23): 2456 - 2467.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A. A. Alsaddique
Recognition of diastolic heart failure in the postoperative heart
Eur. J. Cardiothorac. Surg., December 1, 2008; 34(6): 1141 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
S. V. Chatzikyriakou, D. N. Tziakas, G. K. Chalikias, D. A. Stakos, A. K. Thomaidi, K. Mitrousi, A. E. Lantzouraki, S. Kotsiou, E. Maltezos, and H. Boudoulas
Serum levels of collagen type-I degradation markers are associated with vascular stiffness in chronic heart failure patients
Eur J Heart Fail, December 1, 2008; 10(12): 1181 - 1185.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
H.-M. Cheng, W.-C. Yu, S.-H. Sung, K.-L. Wang, S.-Y. Chuang, and C.-H. Chen
Usefulness of systolic time intervals in the identification of abnormal ventriculo-arterial coupling in stable heart failure patients
Eur J Heart Fail, December 1, 2008; 10(12): 1192 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W. C. Little
Hypertension, Heart Failure, and Ejection Fraction
Circulation, November 25, 2008; 118(22): 2223 - 2223.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W.H. W. Tang and G. S. Francis
The Year in Heart Failure
J. Am. Coll. Cardiol., November 11, 2008; 52(20): 1671 - 1678.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Guazzi, J. Myers, M. A. Peberdy, D. Bensimhon, P. Chase, and R. Arena
Exercise oscillatory breathing in diastolic heart failure: prevalence and prognostic insights
Eur. Heart J., November 2, 2008; 29(22): 2751 - 2759.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes and Vascular Disease ResearchHome page
H. Von Bibra, M. Diamant, P. G Scheffer, T. Siegmund, and P.-M. Schumm-Draeger
Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease
Diabetes and Vascular Disease Research, November 1, 2008; 5(4): 310 - 318.
[Abstract] [PDF]

Home page
 CJASNHome page
R. Tagore, L. H. Ling, H. Yang, H.-Y. Daw, Y.-H. Chan, and S. K. Sethi
Natriuretic Peptides in Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol., November 1, 2008; 3(6): 1644 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
C. Jarnert, A. Melcher, K. Caidahl, H. Persson, L. Ryden, and M. J. Eriksson
Left atrial velocity vector imaging for the detection and quantification of left ventricular diastolic function in type 2 diabetes
Eur J Heart Fail, November 1, 2008; 10(11): 1080 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
H. Pavlopoulos, J. Grapsa, E. Stefanadi, V. Kamperidis, E. Philippou, D. Dawson, and P. Nihoyannopoulos
The evolution of diastolic dysfunction in the hypertensive disease
Eur J Echocardiogr, November 1, 2008; 9(6): 772 - 778.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, K. Dickstein, A. Cohen-Solal, G. Filippatos, J. J.V. McMurray, P. Ponikowski, P. A. Poole-Wilson, A. Stromberg, D. J. van Veldhuisen, D. Atar, et al.
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
Eur. Heart J., October 1, 2008; 29(19): 2388 - 2442.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
K. Dickstein, A. Cohen-Solal, G. Filippatos, J. J.V. McMurray, P. Ponikowski, P. A. Poole-Wilson, A. Stromberg, D. J. van Veldhuisen, D. Atar, A. W. Hoes, et al.
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
Eur J Heart Fail, October 1, 2008; 10(10): 933 - 989.
[Full Text] [PDF]

Home page
 HeartHome page
G J King, R T Murphy, I Almuntaser, K Bennett, E Ho, and A S Brown
Alterations in myocardial stiffness in elite athletes assessed by a new Doppler index
Heart, October 1, 2008; 94(10): 1323 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc ImagingHome page
T. H. Marwick and M. Schwaiger
The Future of Cardiovascular Imaging in the Diagnosis and Management of Heart Failure, Part 2: Clinical Applications
Circ Cardiovasc Imaging, September 1, 2008; 1(2): 162 - 170.
[Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
W. T. Emery, I. Jadavji, J. B. Choy, and R. A. Lawrance
Investigating the European Society of Cardiology Diastology Guidelines in a practical scenario
Eur J Echocardiogr, September 1, 2008; 9(5): 685 - 691.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
M. L. Handoko and W. J. Paulus
Polishing the diastolic dysfunction measurement stick
Eur J Echocardiogr, September 1, 2008; 9(5): 575 - 577.
[Full Text] [PDF]

Home page
 HeartHome page
A. A Voors and R. M de Jong
Treating diastolic heart failure
Heart, August 1, 2008; 94(8): 971 - 972.
[Full Text] [PDF]

Home page
 HeartHome page
N R Van de Veire, J De Sutter, J J Bax, and J R T C Roelandt
Technological advances in tissue Doppler imaging echocardiography
Heart, August 1, 2008; 94(8): 1065 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc ImagingHome page
T. H. Marwick and M. Schwaiger
The Future of Cardiovascular Imaging in the Diagnosis and Management of Heart Failure, Part 1: Tasks and Tools
Circ Cardiovasc Imaging, July 1, 2008; 1(1): 58 - 69.
[Full Text] [PDF]

Home page
 HypertensionHome page
A. Y-M. Wang, M. Wang, C. W-K. Lam, I. H-S. Chan, Y. Zhang, and J. E. Sanderson
Left Ventricular Filling Pressure by Doppler Echocardiography in Patients With End-Stage Renal Disease
Hypertension, July 1, 2008; 52(1): 107 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
D. Rusinaru, L. Leborgne, M. Peltier, and C. Tribouilloy
Effect of atrial fibrillation on long-term survival in patients hospitalised for heart failure with preserved ejection fraction
Eur J Heart Fail, June 1, 2008; 10(6): 566 - 572.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
L Ingle, J G F Cleland, and A L Clark
Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure"
Heart, June 1, 2008; 94(6): 748 - 753.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. Wang, D. S. Khoury, Y. Yue, G. Torre-Amione, and S. F. Nagueh
Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure
Eur. Heart J., May 2, 2008; 29(10): 1283 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
P. Lindqvist, G. Wikstrom, and A. Waldenstrom
The use of E/Em and the time interval difference of isovolumic relaxation (TIVRT-IVRTm) in estimating left ventricular filling pressures
Eur J Heart Fail, May 1, 2008; 10(5): 490 - 497.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
G W K Yip, M Wang, T Wang, S Chan, J W H Fung, L Yeung, T Yip, S-T Lau, C-P Lau, M-O Tang, et al.
The Hong Kong diastolic heart failure study: a randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fraction
Heart, May 1, 2008; 94(5): 573 - 580.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. M. Chin and L. J. Rubin
Pulmonary arterial hypertension.
J. Am. Coll. Cardiol., April 22, 2008; 51(16): 1527 - 1538.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Westermann, M. Kasner, P. Steendijk, F. Spillmann, A. Riad, K. Weitmann, W. Hoffmann, W. Poller, M. Pauschinger, H.-P. Schultheiss, et al.
Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction
Circulation, April 22, 2008; 117(16): 2051 - 2060.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Nozohoor, J. Nilsson, C. Luhrs, A. Roijer, and J. Sjogren
Influence of Prosthesis-Patient Mismatch on Diastolic Heart Failure After Aortic Valve Replacement
Ann. Thorac. Surg., April 1, 2008; 85(4): 1310 - 1317.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
J. Grewal, R. McKelvie, E. Lonn, P. Tait, J. Carlsson, M. Gianni, C. Jarnert, and H. Persson
BNP and NT-proBNP predict echocardiographic severity of diastolic dysfunction
Eur J Heart Fail, March 1, 2008; 10(3): 252 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
E. Konduracka, A. Gackowski, P. Rostoff, D. Galicka-Latala, W. Frasik, and W. Piwowarska
Diabetic cardiomyopathy: a controversial entity: reply
Eur. Heart J., February 2, 2008; 29(4): 565 - 565.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
O. W. Nielsen, L. Kober, and C. Torp-Pedersen
Heart failure with preserved ejection fraction: dangerous, elusive, and difficult
Eur. Heart J., February 1, 2008; 29(3): 285 - 287.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
J. J.V. McMurray, P. E. Carson, M. Komajda, R. McKelvie, M. R. Zile, A. Ptaszynska, C. Staiger, J. M. Donovan, and B. M. Massie
Heart failure with preserved ejection fraction: Clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial
Eur J Heart Fail, February 1, 2008; 10(2): 149 - 156.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. van Heerebeek, N. Hamdani, M. L. Handoko, I. Falcao-Pires, R. J. Musters, K. Kupreishvili, A. J.J. Ijsselmuiden, C. G. Schalkwijk, J. G.F. Bronzwaer, M. Diamant, et al.
Diastolic Stiffness of the Failing Diabetic Heart: Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension
Circulation, January 1, 2008; 117(1): 43 - 51.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.