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European Heart Journal Advance Access published online on April 12, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm046
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Hyponatraemia in heart failure: a call for redefinition

Jalal K. Ghali

Wayne State University, University Health Center, 2E, Detroit, MI 48201, USA

Corresponding author. Tel: +1 313 745 6252; fax: +1 313 993 0645. E-mail address: jghali@med.wayne.edu

This editorial refers to ‘Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF Registry’ by M. Gheorghiade et al., doi:10.1093/eurheartj/ehl542

The first 10% of the full text of this article appears below.

Hyponatraemia, defined as a serum sodium concentration of <136 mol/L (1 mmol/L = 1 meq/L), is the most common electrolyte abnormality in hospitalized patients with a prevalence of 1–45% depending on the clinical setting, patient population, and the serum value used to define it.1

In heart failure, this has been associated with increased risk of haemodynamic deterioration, longer hospital stay, and higher rehospitalization and higher mortality.2–5 Hyponatraemia in patients with heart failure is also a marker of activation of the renin–angiotensin–aldosterone system with higher levels of renin, angiotensin II, aldosterone, . . . [Full Text of this Article]


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Related articles in EHJ:

Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry
Mihai Gheorghiade, William T. Abraham, Nancy M. Albert, Wendy Gattis Stough, Barry H. Greenberg, Christopher M. O'Connor, Lilin She, Clyde W. Yancy, James Young, Gregg C. Fonarow, and on behalf of the OPTIMIZE-HF Investigators and Coordinators
EHJ 2007 28: 980-988. [Abstract] [FREE Full Text]  



This article has been cited by other articles:


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Hyponatremia Predicts Right Heart Failure and Poor Survival in Pulmonary Arterial Hypertension
Am. J. Respir. Crit. Care Med., June 15, 2008; 177(12): 1364 - 1369.
[Abstract] [Full Text] [PDF]