European Heart Journal Advance Access published online on June 7, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm149
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The red wine hypothesis: from concepts to protective signalling molecules
Department of Medicine, Faculty of Health Sciences, Hatter Cardiovascular Research Institute, University of Cape Town, Private Bag 3, 7935 Observatory, South Africa
Received 30 January 2007; revised 28 March 2007; accepted 5 April 2007.
* Corresponding author. Tel: +27 21 406 6358; fax: +27 21 447 8789. E-mail address: lionel.opie{at}uct.ac.za
We review evidence for and against the ‘red wine hypothesis’, whereby red wine is more likely to confer cardiovascular benefits than white. As background, there is a strong epidemiological and mechanistic evidence for J-shaped relation between alcohol intake and total mortality. However, epidemiological data favouring a specific benefit of red over white wine are not strong and the ‘French paradox’ could at least in part be explained by confounding factors. More convincing evidence is that human studies with de-alcoholized red but not white wine show short-term cardiovascular benefits. The specific components of the de-alcoholized wine that are active on cardiovascular endpoints, are the polyphenols found in red wine, especially resveratrol. The effects of resveratrol on isolated tissues or organs are well-described including molecular mechanisms leading to decreased arterial damage, decreased activity of angiotensin-II, increased nitric oxide, and decreased platelet aggregation. Anti-ischaemic effects include stimulation of prosurvival paths, decreased LDL-oxidation, atheroma, and on the ischaemic-beneficial metabolic changes. Most recently, the agonist effect of resveratrol on the anti-senescence factor sirtuin has lessened cell death in myocytes from failing hearts. Mechanistic feasibility strengthens the case for prospective therapeutic trials of alcohol vs. red wine vs. resveratrol, for example in those with heart failure.
Key Words: Wine • Alcohol • Resveratrol • Molecular mechanisms • Sirtuin
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