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European Heart Journal Advance Access published online on June 11, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm193
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Cardiac involvement in systemic inflammatory diseases

Daniel C. Knockaert

Department of General Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium

Received 2 August 2006; revised 16 February 2007; accepted 26 April 2007.

Corresponding author. Tel: +32 16 34 42 75; fax: +32 16 34 42 30. E-mail address: daniel.knockaert{at}uz.kuleuven.ac.be

Systemic inflammatory diseases represent a large group of rare diseases that may involve all organs and also the heart. The three layers of the heart can be affected and some manifestations such as pericarditis in systemic lupus erythematosus are rather well known, yet others are not known even for cardiologists. Modern sophisticated imaging techniques reveal cardiac abnormalities in most of these diseases and the reported frequency of cardiac involvement ranges widely depending upon the applied diagnostic methods and selection of patients. The clinical significance of these findings is not always established. However, better knowledge and awareness of cardiac involvement is necessary because it conveys a major risk for mortality in several of these rare diseases.

Key Words: Multisystem diseases • Vasculitis • Systemic inflammatory diseases • Aneurysm • Cardiac involvement

This paper was guest edited by Prof. Loic Guillevin, Hospital Cochin, University of Paris, France


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