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European Heart Journal Advance Access published online on June 22, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm213
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Risk area, infarct size, and the exposure of the wavefront phenomenon of myocardial necrosis in humans

Bernhard L. Gerber

Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc, Université Catholique de Louvain, Avenue Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium

Corresponding author: Tel: +32 2 7642803; fax: +32 2 7642811. E-mail address: bernhard.gerber@clin.ucl.ac.be

This editorial refers to ‘Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging’ by Ortiz-Perez et al., doi: 10.1093/eurheartj/ehm212.

The first 150 words of the full text of this article appear below.

In the 1970s, Reimer and Jennings1 performed a multitude of studies in dogs after acute coronary occlusion in which they examined the relation between duration of ischaemia, area at risk, collateral blood flow, and final infarct size. The results of their experiments were summarized by the concept of ‘wavefront phenomenon of myocardial death’. In summary, this concept states that infarct size increases in a transmural wavefront extending from the endocardium to the epicardium with increasing duration of coronary occlusions and with increasing severity of ischaemia. Coronary occlusions lasting <6 h result in subendocardial infarcts, in which infarct size is smaller than the ischaemic area at risk, because some epicardial rim of viable tissue is spared. When coronary occlusion exceeds 6 h, infarcts become transmural with an infarct size encompassing the entire area at risk.

The concept of Reimer and Jennings is fundamental to current revascularization therapy of acute ST-elevation myocardial . . . [Full Text of this Article]


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Related articles in EHJ:

Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging
José T. Ortiz-Pérez, Sheridan N. Meyers, Daniel C. Lee, Preeti Kansal, Francis J. Klocke, Thomas A. Holly, Charles J. Davidson, Robert O. Bonow, and Edwin Wu
EHJ 2007 28: 1750-1758. [Abstract] [FREE Full Text]  



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