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European Heart Journal Advance Access published online on July 19, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm283
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

When and how does cardiac resynchronization therapy reduce dynamic mitral regurgitation?

Luc A. Piérard* and Patrizio Lancellotti*

Department of Cardiology, University Hospital Sart Tilman, B-4000 Liège, Belgium

* Corresponding authors. Tel. +32-4-366-71-94; fax +32-4-366-71-95. E-mail address: lpierard@chu.ulg.ac.be and plancellotti@chu.ulg.ac.be

This editorial refers to ‘Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with LV dyssynchrony, remodelling and cardiopulmonary performance’ by J. Madaric et al., doi:10.1093/eurheartj/ehm126

The first 10% of the full text of this article appears below.

Cardiac resynchronization therapy (CRT) improves clinical status, quality of life, and exercise capacity, promotes reverse left ventricular (LV) remodelling, and prolongs survival of selected heart failure patients with intraventricular conduction delay.1,2 However, 30% of patients do not respond to CRT. Response to CRT largely depends on the extent of LV dyssynchrony, but also on the severity of functional mitral regurgitation (MR). Responders are characterized by a decrease in LV dyssynchrony—restoration of a more normal ventricular activation pattern—and in MR degree.

Functional MR results from an imbalance between tethering forces—annular dilatation, LV dilatation, papillary . . . [Full Text of this Article]


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Related articles in EHJ:

Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with left ventricular dyssynchrony, remodelling and cardiopulmonary performance
Juraj Madaric, Marc Vanderheyden, Christophe Van Laethem, Katia Verhamme, Ann Feys, Marc Goethals, Sofie Verstreken, Peter Geelen, Martin Penicka, Bernard De Bruyne, and Jozef Bartunek
EHJ 2007 28: 2134-2141. [Abstract] [FREE Full Text]  



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