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European Heart Journal Advance Access published online on August 7, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm333
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Fractional flow reserve after previous myocardial infarction

Nico H. J. Pijls

Department of Cardiology, Catharina Hospital Eindhoven, PO Box 1350, 5602 ZA Eindhoven, The Netherlands.

Corresponding author. Tel: +31 (40) 239 7004; fax: +31 (40) 244 7885. E-mail address: nico.pijls@inter.nl.net

This editorial refers to ‘Hyperaemic microvascular resistance is not increased in viable myocardium after chronic myocardial infarction’ by K. M. Marques et al., doi:10.1093/eurheartj/ehm309

The first 10% of the full text of this article appears below.

Marques and colleagues have conducted an interesting study on microvascular resistance of viable tissue within an infarcted area.1 This study is important, not only from a conceptual point of view, but also because it has several relevant implications for the applicability of MIBI spect and fractional flow reserve (FFR) measurement in patients with previous myocardial infarction and a residual or recurrent stenosis in the infarct-related coronary artery.

The use of these methods, one non-invasive and the other invasive, has been supported by theoretical and empirical data, but the present study corroborates their usefulness in patients with previous myocardial infarctions.

To understand the clinical implications of the study by Marques et al., it is paramount to understand microvascular resistance, which so far has been hard to assess in conscious humans.

Microvascular resistance equals the ratio of distal coronary pressure divided by myocardial blood flow. . . . [Full Text of this Article]


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Related articles in EHJ:

Hyperaemic microvascular resistance is not increased in viable myocardium after chronic myocardial infarction
Koen M. Marques, Paul Knaapen, Ronald Boellaard, Nico Westerhof, Adriaan A. Lammertsma, Cees A. Visser, and Frans C. Visser
EHJ 2007 28: 2320-2325. [Abstract] [FREE Full Text]