European Heart Journal Advance Access published online on August 31, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm361
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Diabetes-specific cardiomyopathy in type 1 diabetes mellitus: no evidence for its occurrence in the era of intensive insulin therapy
1 Department of Coronary Disease, Jagiellonian University School of Medicine, ul. Pradnicka 80, Krakow 31-202, Poland
2 Department of Metabolic Diseases, Jagiellonian University School of Medicine, Krakow, Poland
3 Department of Pathology, The John Paul II Hospital, Krakow, Poland
Received 26 January 2007; revised 17 July 2007; accepted 26 July 2007.
* Corresponding author. Tel/fax: +48 12 633 67 44. E-mail address: prostoff{at}vp.pl
Aims: The incidence of diabetic cardiomyopathy, independent of arterial hypertension (AH) and coronary heart disease (CHD), remains controversial. The present study aimed to determine the influence of type 1 diabetes mellitus (T1DM) of long duration (>10 years) on myocardial function estimated by echocardiography (ECHO) and serum level of N-terminal pro-B type natriuretic peptide (NT-proBNP) in patients without CHD and AH. We also retrospectively investigated the relationship between the structural changes in the hearts of other deceased T1DM patients, and had their myocardial function echocardiographically assessed before death.
Methods and results: In 185 patients (96 males) with T1DM (mean duration 22.8 years) and 105 non-diabetic control subjects (57 males), detailed ECHO parameters and NT-proBNP were assessed. No significant differences were found between the respective groups. Histological studies of 17 hearts of deceased T1DM patients were carried out and retrospectively compared with their ECHO performed before death. Histological changes were identified, although without the signs of myocardial dysfunction on ECHO prior to death.
Conclusion: Even the application of echocardiographic, biochemical and morphologic techniques hardly gives sufficient grounds to believe that type 1 diabetes alone may actually precipitate myocardial dysfunction, despite long-term course of the disease and typical histological changes in the myocardium.
Key Words: Diabetic cardiomyopathy • Echocardiography • NT-proBNP • Autopsy reports • Type 1 diabetes mellitus
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. D. Karamitsos, A. Tsapas, and J. R. Arnold Diabetic cardiomyopathy: a controversial entity Eur. Heart J., February 2, 2008; 29(4): 564 - 564. [Full Text] [PDF]
|
|
|
|
|
|
E. Konduracka, A. Gackowski, P. Rostoff, D. Galicka-Latala, W. Frasik, and W. Piwowarska Diabetic cardiomyopathy: a controversial entity: reply Eur. Heart J., February 2, 2008; 29(4): 565 - 565. [Full Text] [PDF]
|
|