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European Heart Journal Advance Access published online on October 11, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm371
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Renin turning full circle as cardiovascular risk factor

Ahmet Adiyaman1,2 and Jan A. Staessen1,*

1 Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
2 Department of Cardiology, Heart Lung Centre, Radboud University Medical Centre, Nijmegen, The Netherlands

* Corresponding author. E-mail address: jan.staessen@med.kuleuven.be

This editorial refers to ‘Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study’ by N.I. Parikh et al., doi:10.1093/eurheartj/ehm399

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Renin released from the kidneys, along the cascade of the renin–angiotensin–aldosterone axis, is a major regulator of blood pressure via the generation of angiotensin II and of body sodium and potassium via aldosterone release. Under normal conditions, renin decreases with age and higher blood pressure, whereas salt depletion stimulates renin release. In 1972, Brunner and Laragh first introduced the concept of classifying hypertensive patients according to plasma renin activity in relation to the daily sodium excretion.1 Among patients with essential hypertension, those with normal (57%) or high (16%) renin had an 11 and 14% frequency of heart attacks or strokes, respectively, whereas none of the low . . . [Full Text of this Article]


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Related articles in EHJ:

Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study
Nisha I. Parikh, Philimon Gona, Martin G. Larson, Thomas J. Wang, Christopher Newton-Cheh, Daniel Levy, Emelia J. Benjamin, William B. Kannel, and Ramachandran S. Vasan
EHJ 2007 28: 2644-2652. [Abstract] [Full Text]