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European Heart Journal Advance Access published online on October 12, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm451
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Free fatty acids, cardiovascular mortality, and cardiometabolic stress

Dariush Mozaffarian*

Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, and Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA

* Corresponding author: Tel: +1 617 432 2887; fax: +1 617 432 2435; E-mail address: dmozaffa@hsph.harvard.edu

This editorial refers to ‘Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography’ by S. Pilz et al., doi:10.1093/eurheartj/ehm343

The first 10% of the full text of this article appears below.

Free fatty acids (FFAs) are non-esterified fatty acids that circulate in the bloodstream predominantly bound to albumin. FFAs are released from adipocyte triglyceride stores by lipolysis and from phospholipids by the action of phospholipases. Release of FFAs, as well as uptake of circulating FFAs by tissues such as skeletal muscle and liver, is regulated by the action of insulin and modulated by adrenergic activity. FFAs represent a significant energy source, being oxidized by myocardium, skeletal muscle, liver, and kidney. Specific FFAs may also directly regulate cellular function, either by exchange with membrane phospholipid fatty acids or in their role as natural ligands of cytoplasmic nuclear receptors, such as peroxisome proliferator-activated receptors.

Utilizing data from a prospective cohort study . . . [Full Text of this Article]


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Related articles in EHJ:

Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography
Stefan Pilz, Hubert Scharnagl, Beate Tiran, Britta Wellnitz, Ursula Seelhorst, Bernhard O. Boehm, and Winfried März
EHJ 2007 28: 2763-2769. [Abstract] [FREE Full Text]