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European Heart Journal Advance Access published online on October 24, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm456
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© The European Society of Cardiology, the American Heart Association, Inc, and the American College of Cardiology Foundation 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The role of endomyocardial biopsy in the management of cardiovascular disease

A Scientific Statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology

Leslie T. Cooper, MD, FAHA, FACC, Kenneth L. Baughman, MD, FAHA, FACC, Arthur M. Feldman, MD, PhD, FAHA, FACC, Andrea Frustaci, MD, Mariell Jessup, MD, FAHA, FACC, Uwe Kuhl, MD, Glenn N. Levine, MD, FAHA, FACC, Jagat Narula, MD, PhD, FAHA, Randall C. Starling, MD, MPH, Jeffrey Towbin, MD, FAHA, FACC and Renu Virmani, MD, FACC

Key Words: Scientific statements • Biopsy • Transplantation • Heart failure • Cardiomyopathy • Myocarditis

The first 150 words of the full text of this article appear below.

The role of endomyocardial biopsy (EMB) in the diagnosis and treatment of adult and pediatric cardiovascular disease remains controversial, and the practice varies widely even among cardiovascular centers of excellence. A need for EMB exists because specific myocardial disorders that have unique prognoses and treatment are seldom diagnosed by noninvasive testing.1 Informed clinical decision making that weighs the risks of EMB against the incremental diagnostic, prognostic, and therapeutic value of the procedure is especially challenging for nonspecialists because the relevant published literature is usually cited according to specific cardiac diseases, which are only diagnosed after EMB. To define the current role of EMB in the management of cardiovascular disease, a multidisciplinary group of experts in cardiomyopathies and cardiovascular pathology was convened by the American Heart Association (AHA), the American College of Cardiology (ACC), and the European Society of Cardiology (ESC). The present Writing Group was charged with reviewing the published . . . [Full Text of this Article]


   Technique and risks of EMB
 

   Analysis of EMB tissue
 
EMB processing
Light microscopic examination and stains
Molecular biological detection of viral genomes

   When should EMB be performed?
 
Clinical scenario 1
Clinical Scenario 2
Clinical scenario 3
Clinical scenario 4
Clinical scenario 5
Clinical scenario 6
Clinical scenario 7
Clinical scenario 8
Clinical scenario 9
Clinical scenario 10
Clinical scenario 11
Clinical scenario 12
Clinical scenario 13
Clinical scenario 14

   EMB as a research tool
 

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