European Heart Journal Advance Access published online on December 21, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm535
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
Peripheral arterial disease enters the biomarker era. Does risk stratification tell us something that we don't already know?
Department of CV Medicine, Cleveland Clinic, 9500 Euclid Avenue–Desk S60, Cleveland, OH 44195, USA
* Corresponding author. Tel: +1 216 445 3689, Fax: +1 216 444 7370, Email: gornikh@ccf.org
This editorial refers to Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease by G. Brevetti et al., doi:10.1093/eurheartj/ehm587
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After decades of obscurity, peripheral arterial disease (PAD) is gaining recognition as a serious cardiovascular (CV) disorder. It is estimated that >27 million individuals in Europe and the USA have PAD, though there remains a widespread lack of awareness of this disorder among at-risk patients and healthcare professionals.1,2 In addition to functional impairment and related effects on quality of life, individuals with PAD are at a markedly increased risk of a major CV event, namely myocardial infarction (MI), stroke, and death.
Brevetti and colleagues have investigated the utility of two inflammatory biomarkers, high sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO), to stratify CV risk among patients with PAD.3 A cohort of 156 patients with intermittent claudication and an ankle–brachial index (ABI)
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- Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease
- Gregorio Brevetti, Vittorio Schiano, Eugenio Laurenzano, Giuseppe Giugliano, Mario Petretta, Francesco Scopacasa, and Massimo Chiariello
EHJ 2008 29: 224-230.[Abstract] [FREE Full Text]