Skip Navigation



European Heart Journal Advance Access published online on December 15, 2007
European Heart Journal, doi:10.1093/eurheartj/ehm576
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
29/6/784    most recent
ehm576v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mattsson, N.
Right arrow Articles by Raitakari, O. T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mattsson, N.
Right arrow Articles by Raitakari, O. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study

Noora Mattsson1, Tapani Rönnemaa2, Markus Juonala1,2, Jorma S.A. Viikari2, Eero Jokinen3, Nina Hutri-Kähönen4, Mika Kähönen5, Tomi Laitinen6 and Olli T. Raitakari7,*

1 The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
2 Department of Medicine, University of Turku, Finland
3 Department of Pediatrics, University of Helsinki, Finland
4 Department of Pediatrics, University of Tampere, Finland
5 Department of Clinical Physiology, University of Tampere, Finland
6 Department of Clinical Physiology, University of Kuopio, Finland
7 Department of Clinical Physiology, University of Turku, Kiinamyllynkatu 4-8, FIN-20521 Turku, Finland

Received 7 May 2007; revised 19 October 2007; accepted 15 November 2007.

* Corresponding author. Tel: +358 2 313 1828, Fax: +358 2 313 1666, Email: olli.raitakari{at}utu.fi

Aims: To study the relations between the metabolic syndrome (MS) and subclinical atherosclerosis in young adults.

Methods and results: International Diabetes Federation (msIDF), National Institute of Health Adult Treatment Panel III (msNCEP), and European Group for the Study of Insulin Resistance (msEGIR) definitions of MS were related to carotid artery intima–media thickness (cIMT), brachial flow-mediated dilatation (FMD), and carotid artery compliance (CAC) in 2163 Finnish adults (aged 32 ± 5years). All definitions associated with increased cIMT and decreased CAC in both sexes. The cIMT values (mean ± SD) were 0.576 ± 0.088 mm in subjects without the syndrome, 0.615 ± 0.102 mm in msIDF, 0.617 ± 0.104 mm in msNCEP, and 0.607 ± 0.097 mm in msEGIR (P < 0.0001). Corresponding CAC values were 2.26 ± 0.72, 1.76 ± 0.66, 1.73 ± 0.66, 1.72 ± 0.66%/10 mmHg (P < 0.001). Impaired brachial FMD was not related to MS but it modified the relations between MS and cIMT: MS correlated with increased cIMT in subjects with an impaired FMD response (P = 0.003) but not in subjects with an enhanced FMD response (P = 0.75).

Conclusion: All current definitions of MS identify a population of young adults with evidence of increased subclinical atherosclerosis. Impaired brachial endothelial response is not a hallmark of MS in young adults, but the status of endothelial function modifies the association between metabolic risk factors and atherosclerosis.

Key Words: Metabolic syndrome • Carotid intima-media thickness • Carotid compliance • Brachial flow-mediated dilatation • Atherosclerosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
F.L.J. Visseren
Vascular consequences of metabolic syndrome in early life
Eur. Heart J., March 2, 2008; 29(6): 693 - 694.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.