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European Heart Journal Advance Access published online on March 10, 2008
European Heart Journal, doi:10.1093/eurheartj/ehm594
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Atrial fibrillation subtypes, risk of stroke, and antithrombotic therapy

Marco Stramba-Badiale*

Department of Rehabilitation Medicine, IRCCS Istituto Auxologico Italiano, Via Mosè Bianchi, 90, 20149 Milano, Italy

* Corresponding author. Tel: +39 02 619112850, Fax: +39 02 619112850, Email: stramba_badiale@auxologico.it

This editorial refers to ‘Should we abandon the common practice of withholding oral anticoagulation in paroxysmal atrial fibrillation?’ by R. Nieuwlaat et al., doi:10.1093/eurheartj/ehn101.

The first 10% of the full text of this article appears below.

Despite a significant decline in the last 50 years, stroke remains the third leading cause of mortality in men and the second in women.1 Stroke also represents the leading cause of disability and the second of dementia, with a tremendous impact on the affected patients and their relatives. Approximately one-third of ischaemic strokes are caused by an embolus originating from the heart, and in the majority of these cases atrial fibrillation is responsible for the thromboembolic event. This proportion may be even higher, as the role of atrial fibrillation in the pathogenesis of stroke may be underestimated. In fact, the observation of sinus rhythm on the surface electrocardiogram at hospital admission for stroke, in the absence of clinical history of atrial fibrillation, does not rule out the possibility of a new-onset and self-terminating arrhythmic episode that preceded the occurrence of neurological . . . [Full Text of this Article]


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