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European Heart Journal Advance Access published online on January 17, 2008
European Heart Journal, doi:10.1093/eurheartj/ehm607
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Clinical value, cost-effectiveness, and safety of myocardial perfusion scintigraphy: a position statement

Claudio Marcassa1,*, Jeroen J. Bax2, Frank Bengel3, Birger Hesse4, Claus L. Petersen5, Eliana Reyes6, Richard Underwood on behalf of the European Council of Nuclear Cardiology (ECNC), the European Society of Cardiology Working Group 5 (Nuclear Cardiology and Cardiac CT), and the European Association of Nuclear Medicine Cardiovascular Committee6

1 Cardiology Department, S. Maugeri Foundation, IRCCS, Scientific Institute of Veruno, V. Revislate 13, 28010 Veruno, NO, Italy
2 Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
3 Division of Nuclear Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA
4 Department of Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
5 Department of Nuclear Medicine, Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark
6 National Heart and Lung Institute, Imperial College London, London, UK

Received 15 August 2007; revised 15 November 2007; accepted 6 December 2007.

* Corresponding author. Tel: +39 0322884711, Fax: +39 0322884269, Email: claudio.marcassa{at}fsm.it

Mortality rates due to coronary artery disease (CAD) have declined in recent years as result of improved prevention, diagnosis, and management. Nonetheless, CAD remains the leading cause of death worldwide with most casualties expected to occur in developing nations. Myocardial perfusion scintigraphy (MPS) provides a highly cost-effective tool for the early detection of obstructive CAD in symptomatic individuals and contributes substantially to stratification of patients according to their risk of cardiac death or nonfatal myocardial infarction. MPS also provides valuable information that assists clinical decision-making with regard to medical treatment and intervention. A large body of evidence supports the current applications of MPS, which has become integral to several guidelines for clinical practice.

Key Words: Coronary artery disease • Cost-effectiveness • Myocardial perfusion scintigraphy • Radionuclide • Scintigraphy


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