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European Heart Journal Advance Access published online on January 3, 2008
European Heart Journal, doi:10.1093/eurheartj/ehm608
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Is adiponectin and its genetic regulators useful or not for prediction of carotid intima-media thickness and coronary heart disease?

Peter M. Nilsson

Department of Clinical Sciences Medicine, University Hospital, University of Lund, Malmö, Sweden

Corresponding author. Tel: +46 40 33 24 15, Fax: +46 40 92 32 72, Email: Peter.Nilsson@med.lu.se

This editorial refers to ‘Variation in the ADIPOQ gene promoter is associated with carotid intima-media thickness independent of plasma adiponectin levels in healthy subjects’ by S. Patel et al., doi:10.1093/eurheartj/ehm526

The first 10% of the full text of this article appears below.

The abdominal adipose tissue is now generally regarded as an important endocrine organ, secreting a wide range of adipokines and other regulatory peptides or hormones. One of these adipokines that has attracted a great deal of interest is adiponectin, which can be detected in various molecular forms.1 Its synthesis is regulated by the ADIPOQ gene promoter. Adiponectin has been implicated to be a marker of insulin sensitivity and glucose metabolism, as well as being involved in inflammatory processes.1,2 Previous studies have shown an inverse correlation between circulating adiponectin levels and measures of insulin resistance, as well as C-reactive protein (CRP) levels. It is still an open question whether or not adiponectin plays a causal and independent role in the development of arterial lesions due to atherosclerosis, resulting in increased risk of cardiovascular . . . [Full Text of this Article]


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Related articles in EHJ:

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects
Sheila Patel, Allan Flyvbjerg, Michaela Kozàkovà, Jan Frystyk, Ibrahim M. Ibrahim, John R. Petrie, Peter J. Avery, Ele Ferrannini, Mark Walker, and the RISC Investigators
EHJ 2008 29: 386-393. [Abstract] [Full Text]