European Heart Journal Advance Access published online on February 27, 2008
European Heart Journal, doi:10.1093/eurheartj/ehm642
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
Vascular consequences of metabolic syndrome in early life
Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
Corresponding author. Tel. +31 88 755 5555, Fax +31 30 250 5488, Email: F.L.J.Visseren@umcutrecht.nl
This editorial refers to Arterial structure and function in young adults with the metabolic syndrome. The Cardiovascular Risk in Young Finns Study by N. Mattson et al. doi:10.1093/eurheartj/ehm576
| The first 10% of the full text of this article appears below. |
The presence of the metabolic syndrome, a clustering of metabolic risk factors closely associated with abdominal obesity, is accompanied by an increased risk for the development of cardiovascular diseases and type 2 diabetes mellitus. It is now generally accepted that insulin resistance together with abdominal obesity are key features in the pathophysiology of the metabolic syndrome. As a result of total body energy dysbalance, adipocytes in abdominal adipose tissue enlarge and start producing chemotactic factors, such as monocyte chemoattractant protein-1 (MCP-1) attracting monocytes/macrophages. This dysfunctional abdominal adipose tissue produces large quantities of free fatty acids, adipokines, and inflammatory cytokines, e.g. interleukin-6 (IL-6) and
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