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European Heart Journal Advance Access published online on March 10, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn075
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Developing the utility of blood biomarker associations beyond population sample linkage to events in cardiovascular patients

Robert J. MacFadyen* and M. Jennyfer Ng Kam Chuen

University Department of Medicine and Department of Cardiology, City Hospital, Dudley Road, Birmingham B18 7QH, UK

* Corresponding author. Tel: +44 121 507 4476/5080, Fax: +44 121 554 4083, Email: Robert.macfadyen@swbh.nhs.uk

This editorial refers to ‘The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study’ by M.J. West et al., doi:10.1093/eurheartj/ehn007

The first 10% of the full text of this article appears below.

West et al.1 report a small, well designed post hoc nested case–control sample from the LIPID trial of pravastatin.2 This was completed in low risk subjects with documented coronary disease in the form of a previous confirmed acute coronary syndrome (ACS). This additional report examines biomarker linkage over a relatively short time frame of 2–3 years and highlights two measurements perhaps not intuitively linked to the biology of coronary disease progression. The conditional logistic regression analysis shows a significant linkage association following point analysis for N-terminal brain natriuretic peptide (NT-BNP) and tissue metalloproteinase-1 (TIMP-1). TIMP-1 has been linked to cardiovascular events in low risk patients previously, in patients with less well confirmed coronary disease.3 Its re-affirmation here as a population predictor of events in this group of patients is of value. Similarly for NT-BNP, which is frequently presumed . . . [Full Text of this Article]


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Related articles in EHJ:

The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study
Malcolm J. West, Paul J. Nestel, Adrienne C. Kirby, Renate Schnabel, David Sullivan, R. John Simes, Christine Pollicino, Edith Lubos, Thomas F. Münzel, Harvey D. White, Andrew M. Tonkin, Christoph Bickel, Laurence Tiret, Stefan Blankenberg, and for the LIPID Study Investigators
EHJ 2008 29: 923-931. [Abstract] [Full Text]