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European Heart Journal Advance Access published online on March 26, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn127
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Modulation of cardiac contractility. A potential treatment of heart failure?

J. Claude Daubert*

Département de Cardiologie, Centre cardio-pneumologique, Centre Hospitalier Universitaire, F-35033 Rennes, France

* Corresponding author: Tel: +33 2 99 28 25 25, Fax: +33 2 99 28 25 10, Email: jean-claude.daubert@chu-rennes.fr

This editorial refers to ‘Randomized, double-blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure’{dagger} by M.M. Borggrefe et al., on page 1019

The first 150 words of the full text of this article appear below.

During the last 10 years, electrical treatment of heart failure (HF) has become more and more popular. Cardiac resynchronization therapy (CRT), alone or combined with defibrillation, has been confirmed to be effective in patients with moderate or severe HF and ventricular dyssynchrony, manifest as a QRS duration >120 ms, though its effectiveness has not been confirmed in patients presenting with HF and a narrow QRS.1 As for all new treatments of HF, the clinical validation of CRT has been slow and occurred in four stages, including (i) limited observational studies to establish its feasibility; (ii) short-term, randomized, crossover studies to validate the clinical concept;2,3 (iii) large, controlled, parallel-design trials with a view to measure the clinical impact of this therapy on major morbidity and mortality;4,5 and (iv) publication of clinical guidelines. It took >10 years after the publication of the first case report6 for professional societies to assign CRT a . . . [Full Text of this Article]

Clinical experience with CCM

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Related articles in EHJ:

Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure
Martin M. Borggrefe, Thomas Lawo, Christian Butter, Herwig Schmidinger, Maurizio Lunati, Burkert Pieske, Anand Ramdat Misier, Antonio Curnis, Dirk Böcker, Andrew Remppis, Joseph Kautzner, Markus Stühlinger, Christophe Leclerq, Milos Táborsky, Maria Frigerio, Michael Parides, Daniel Burkhoff, and Gerhard Hindricks
EHJ 2008 29: 1019-1028. [Abstract] [FREE Full Text]