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European Heart Journal Advance Access published online on April 4, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn143
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Novel biomarkers—the long march from bench to bedside

Michael Weber and Christian Hamm*

Kerckhoff Heart Center, Departement of Cardiology, Benekestraße 2–8, D-61231 Bad Nauheim, Germany

* Corresponding author. Tel: +49 6232 9960, Fax: +49 6232 9962313, Email: c.hamm@Kerckhoff-Klinik.de

This editorial refers to ‘Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18’, by D.A. Morrow et al., doi:10.1093/eurheartj/ehn071

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In recent years, a deeper understanding of the pathobiology of atherothrombosis as the underlying mechanism of acute coronary syndromes (ACS) has directed scientific studies towards the evaluation of novel serum biomarkers as potential diagnostic tools for the clinical setting. Prerequisites for a biomarker to enter clinical routine in ACS are several fold. The most important features are that the marker can be offered on a routine platform, provides higher sensitivity and specificity than the electrocardiogram in predicting outcome, and it should impact therapeutic decision making. Markers reflecting increased risk for coronary artery disease, such asserum creatinine, lipid levels or glycated haemoglobin (HbA1C), are only useful in predicting long-term prognosis. For the acute phase, the highest value can be . . . [Full Text of this Article]


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Related articles in EHJ:

Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18
David A. Morrow, Marc S. Sabatine, Marie-Luise Brennan, James A. de Lemos, Sabina A. Murphy, Christian T. Ruff, Nader Rifai, Christopher P. Cannon, and Stanley L. Hazen
EHJ 2008 29: 1096-1102. [Abstract] [Full Text]