European Heart Journal Advance Access published online on April 16, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn149
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Published by Oxford University Press on behalf of the European Society of Cardiology 2008
New cardiovascular risk determinants do exist and are clinically useful
Department of Pathology and Laboratory Medicine
University of Louisville and Laboratory Service
VAMC
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Department of Veterans Affairs
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Email: levinson@louisville.edu
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I read with interest the article by Smulders et al., in which the authors noted that the key to understanding a statistically significant relationship between independent risk predictions, but no improvement in risk classifications, lies with the statistical methodology used for the assessment.1 But, it seems to