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European Heart Journal Advance Access published online on June 24, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn201
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

The visualization of the remodelling paradox

Gerard Pasterkamp* and Imo Hoefer

Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Centre Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands

* Corresponding author. Tel: +31 887557155, Fax: +31 302522693, Email: g.pasterkamp@umcutrecht.nl

This editorial refers to ‘In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography’{dagger} by O.C. Raffel et al., on page 1721

The first 10% of the full text of this article appears below.

In the 1990s, significant efforts and investments were made in the development of imaging technologies with the objective of visualizing and characterizing the atherosclerotic plaque. Although angiography still is the indisputable first choice for the clinical diagnosis of coronary artery luminal narrowing, new imaging modalities are likely to stay to provide surrogate markers for disease progression and treatment efficacy.

Since its clinical introduction, an important role has been arrogated to intravascular ultrasound (IVUS) in the diagnosis of coronary artery disease. However, despite the superior information that is provided on plaque and vessel morphology, IVUS has never met the expectations that were raised more than a decade ago, i.e. that IVUS would be routinely used in the cathlab. IVUS did improve . . . [Full Text of this Article]


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