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European Heart Journal Advance Access published online on May 19, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn226
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Mitral annular calcifications and aortic valve stenosis

M. Pachón and J. Zamorano*

Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain

* Corresponding author. Tel: +34 913303290, Fax: +34-91-3303292, Email: jlzamorano@vodafone.es

This editorial refers to ‘Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progresion observation measuring effects of rosuvastatin (ASTRONOMER) study,’ by D.S. Jassal et al. doi:10.1093/eurheartj/ehn172

The first 10% of the full text of this article appears below.

Idiopathic mitral annular calcification (MAC) is one of the most common cardiac abnormalities found in autopsies, occurring twice as often in females than in males. It has been reported in 6.1% of the subjects that undergo a routine echocardiogram,1 and the incidence rises sharply with age. The primary pathological event in its development is considered to be a fibrillar alteration of the collagen ultrastructure that triggers lipid deposition and calcification within the annulus. Although it was initially thought that the presence of calcification of the mitral annulus had few functional consequences in most hearts, this is not the case. Patients with MAC have been shown to be at a higher risk of conduction disturbances, cardiovascular disease, and total cardiac death. Calcified aortic valve disease is also very common. The overall prevalence is 13% and increases up to 25% in adults >65 years old. Until recently, . . . [Full Text of this Article]


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Related articles in EHJ:

Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study
Davinder S. Jassal, James W. Tam, Kapil M. Bhagirath, Isabelle Gaboury, Randall A. Sochowski, Jean G. Dumesnil, Peter J. Giannoccaro, John Jue, A. Shekhar Pandey, Campbell D. Joyner, Koon K. Teo, and Kwan L. Chan
EHJ 2008 29: 1542-1547. [Abstract] [FREE Full Text]