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European Heart Journal Advance Access published online on June 5, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn243
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Published by Oxford University Press on behalf of the European Society of Cardiology 2008

Vascular form and function: two mechanisms for cardiovascular prevention

Scott Kinlay*

Interventional Cardiology and Vascular Medicine, VA Boston Healthcare System and Brigham and Women's Hospital, 1400 VFW Parkway, West Roxbury, MA 02132, USA

* Corresponding author. Tel: +1 61 525 7052, Fax: +1 617 264 5265, Email: scott.kinlay@va.gov; skinlay@partners.org

This editorial refers to ‘Cholesterol lowering is more important than pleiotropic effects of statins for endothelial function in patients with dysglycaemia and coronary artery disease’ by M. Settergren et al. doi:10.1093/eurheartj/ehn166

The first 10% of the full text of this article appears below.

When Louis Sullivan, of the ‘Chicago School’ of architecture stated that form follows function, he liberated the wave of the Modernist Movement. In its wake, other luminaries including Le Corbusier, Gropius, and Mies van der Rohe changed and challenged the urban landscape into the new century.

Is it any wonder that our reductionist approach to disease and health is also divided between mechanisms of form and those of function? They challenge and change our view of atherosclerosis. The discovery that the endothelium is an autocrine and paracrine organ regulating many functions to prevent the forms of atherosclerosis that cause disease pervades our current constructs. Yet, the importance of atherosclerosis form (size and composition) and arterial function are debated in ways that ignore their close association.

Perhaps equally as beguiling are the mechanisms that determine the change in cardiovascular risk from risk factor . . . [Full Text of this Article]

Statin pleiotropy

Vascular function

Vascular form

Lowering cardiovascular risk


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Related articles in EHJ:

Cholesterol lowering is more important than pleiotropic effects of statins for endothelial function in patients with dysglycaemia and coronary artery disease
Magnus Settergren, Felix Böhm, Lars Rydén, and John Pernow
EHJ 2008 29: 1753-1760. [Abstract] [FREE Full Text]