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European Heart Journal Advance Access published online on June 20, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn274
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Effect of statins in ‘upstream therapy’ of atrial fibrillation: better reliability with implantable cardiac monitors

Carsten W. Israel*

J. W. Goethe University Hospital, Department of Medicine, Division of Cardiology, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany

* Corresponding author. Tel: + 49 69 6301 7387, Fax: + 49 69 6301 3813, Email: C.W.Israel@em.uni-frankfurt.de

This editorial refers to ‘Beneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantation’, by A.M. Gillis et al. doi:10.1093/eurheartj/ehn192

The first 10% of the full text of this article appears below.

The therapeutic potential to suppress atrial fibrillation (AF) is currently under evaluation for several non-antiarrhythmic drugs: angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, anti-inflammatory and antioxidative drugs, polyunsaturated fatty acids, and HMG-CoA reductase inhibitors, i.e. statins.

Statins have shown multiple (‘pleiotropic’) beneficial effects beyond lowering of cholesterol: anti-inflammatory, antioxidant, and antifibrotic effects, modulation of matrix metalloproteinases, interaction with peroxisome receptors that regulate proliferation, and with endothelial nitric oxide synthase, protecting atrial myocardium during ischaemia.1 For these reasons, statins may be able to decelerate or even reverse structural remodelling in patients with AF. Additionally, pre-treatment with . . . [Full Text of this Article]


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Related articles in EHJ:

Beneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantation
Anne M. Gillis, Margaret Morck, Derek V. Exner, Andrea Soo, M. Sarah Rose, Robert S. Sheldon, Henry J. Duff, Katherine M. Kavanagh, L. Brent Mitchell, and D. George Wyse
EHJ 2008 29: 1873-1880. [Abstract] [FREE Full Text]