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European Heart Journal Advance Access published online on July 10, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn321
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Acute and stable coronary heart disease: different risk factors

Stefan Agewall*

Department of Medicine, Aker University Hospital and Oslo University, 0514 Oslo, Norway

* Corresponding author. Tel: + 47 228 94655, Fax: + 47 228 94259, Email: stefan.agewall@medisin.uio.no

This editorial refers to ‘Contribution of novel biomarkers to incident stable angina and acute coronary syndrome. The PRIME study,’ by J.-P. Empana et al. doi:10.1093/eurheartj/ehn331

The first 10% of the full text of this article appears below.

Coronary heart disease (CHD) continues to be a worldwide leading cause of death for both men and women. When coronary atherosclerosis progresses, there is deposition of plaque external to the lumen of the artery, thus the plaque may extend eccentrically and outward without compromising the lumen initially. As atherosclerosis worsens the plaque mass may later on bulge into the lumen and may therefore result in a haemodynamic obstruction and angina pectoris symptoms. Typically, angina pectoris develops when an atherosclerotic plaque obstructs at least 70% of the arterial lumen. Thus, stable angina pectoris is a condition in which there is regional myocardial ischaemia caused by inadequate coronary perfusion and is usually induced by increases in myocardial oxygen requirements. Chest pain that can be characterized as chronic stable angina typically is produced with physical exertion and relieved by rest and/or nitroglycerin. In contrast, chest . . . [Full Text of this Article]

Same disease or two different diseases?

Classical cardiovascular risk factors

Inflammation
The endothelium
von Willebrand factor
Interpretation of the study


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Related articles in EHJ:

Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study
Jean-Philippe Empana, Florence Canoui-Poitrine, Gerald Luc, Irene Juhan-Vague, Pierre Morange, Dominique Arveiler, Jean Ferrieres, Philippe Amouyel, Annie Bingham, Michelle Montaye, Jean-Bernard Ruidavets, Bernadette Haas, Alun Evans, Pierre Ducimetiere, and on behalf of the PRIME Study Group
EHJ 2008 29: 1966-1974. [Abstract] [FREE Full Text]