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European Heart Journal Advance Access published online on July 30, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn349
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Genome-wide association studies of coronary artery disease: have the results of replication studies been replicable?

Chew-Kiat Heng*

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074

* Corresponding author. Tel: +65 67725708, Fax: +65 67742796, Email: paehck@nus.edu.sg

This editorial refers to ‘Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia,’ by J.B. van der Net et al. doi:10.1093/eurheartj/ehn303

The first 10% of the full text of this article appears below.

The recent wave of publications describing genome-wide association (GWA) studies of coronary artery disease (CAD) is beginning to wane. These GWA studies have identified a host of genetic variants that are associated with CAD. As expected, within a span of a few months this initial flood of GWA studies has inspired a matching surge of replication studies. At this juncture it is perhaps pertinent to ask the question: Have the results generated from these studies, thus far, been reproducible?

Findings from the first GWA study for CAD were reported by . . . [Full Text of this Article]


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Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia
Jeroen B. van der Net, Daniëlla M. Oosterveer, Jorie Versmissen, Joep C. Defesche, Mojgan Yazdanpanah, Bradley E. Aouizerat, Ewout W. Steyerberg, Mary J. Malloy, Clive R. Pullinger, John J.P. Kastelein, John P. Kane, and Eric J.G. Sijbrands
EHJ 2008 29: 2195-2201. [Abstract] [FREE Full Text]