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European Heart Journal Advance Access published online on October 17, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn469
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Circulating cells: the biofactory for markers of atherosclerotic disease

Gerard Pasterkamp* and Mat Daemen

Experimental Cardiology Laboratory, Utrecht Medical Center, 3584 CX Utrecht, The Netherlands

* Corresponding author. Tel: +31 302507155, Fax: +31 302522693, Email: g.pasterkamp@hli.azu.nl

This editorial refers to ‘Interleukin-8 is increased in the membrane of circulating erythrocytes in patients with acute coronary syndrome’ by D.N. Tziakas et al. doi:10.1093/eurheartj/ehn382

The first 10% of the full text of this article appears below.

Atherosclerotic cardiovascular disease remains the number one killer of the ageing population in Western society. The natural history of the disease is unknown, and clinical events may strike without any warning. There have long been efforts to discover new biomarkers and to validate surrogate end-points to diagnose patients at risk for acute manifestations of atherosclerotic disease and to test treatment efficacy.

There is increasing evidence that suggests cross-talk between the diseased vascular tree and subsets of circulating cells. Functional, molecular, and structural characteristics of circulating cells may serve as biomarkers for initiation and progression of atherosclerotic disease. Several groups reported that the interleukin-6 (IL-6) release of circulating monocytes following in vitro lipopolysaccharide stimulation . . . [Full Text of this Article]


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Related articles in EHJ:

Interleukin-8 is increased in the membrane of circulating erythrocytes in patients with acute coronary syndrome
Dimitrios N. Tziakas, Georgios K. Chalikias, Ioannis K. Tentes, Dimitrios Stakos, Sofia V. Chatzikyriakou, Konstantina Mitrousi, Alexandros X. Kortsaris, Juan Carlos Kaski, and Harisios Boudoulas
EHJ 2008 29: 2713-2722. [Abstract] [FREE Full Text]  



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