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European Heart Journal Advance Access published online on October 19, 2008
European Heart Journal, doi:10.1093/eurheartj/ehn471
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Right from the heart: when should myocardial biopsy be performed for suspected arrhythmogenic right ventricular cardiomyopathy/dysplasia?

Leslie T. Cooper, Jr*

Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

* Corresponding author: Tel: +1 507 284 3680, Fax: +1 507 266 0228, Email: cooper.leslie@mayo.edu

This editorial refers to ‘Quantitative assessment of endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy/dysplasia: an in vitro validation of diagnostic criteria’{dagger} by C. Basso et al., on page 2760

The first 150 words of the full text of this article appear below.

A host of uncommon but clinically important myocardial diseases including arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) have unique prognoses and treatments and should be strongly suspected in their characteristic clinical scenarios. ARVC/D is an inherited or sporatic form of predominantly right ventricular cardiomyopathy characterized by a progressive loss of myocytes that are replaced by fibrofatty tissue. The typical patient is in their third to fifth decade, and presents with ventricular arrhythmias, palpitations, syncope, or sudden death.1 The ECG may reveal epsilon waves, T-wave inversions, and/or localized QRS complex duration >110 ms in V1–V3. Imaging of the right ventricle by echocardiography, computed tomography (CT), or magnetic resonance imaging (MRI) may reveal focal or global dilatation or aneurysm formation.2 Because cardiac sarcoidosis or focal non-compaction syndrome, which have distinct aetiologies and treatments, can share AVRC/D's clinical features, and non-invasive testing can be inconclusive, histological confirmation of ARVC/D is sometimes necessary.

Basso et . . . [Full Text of this Article]


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Related articles in EHJ:

Quantitative assessment of endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy/dysplasia: an in vitro validation of diagnostic criteria
Cristina Basso, Federico Ronco, Frank Marcus, Aierken Abudureheman, Stefania Rizzo, Anna Chiara Frigo, Barbara Bauce, Francesco Maddalena, Andrea Nava, Domenico Corrado, Francesco Grigoletto, and Gaetano Thiene
EHJ 2008 29: 2760-2771. [Abstract] [FREE Full Text]