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European Heart Journal Advance Access originally published online on April 30, 2007
European Heart Journal 2007 28(10):1178-1179; doi:10.1093/eurheartj/ehm073
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The role of infection in cardiovascular disease: more support but many questions remain

Liam Smeeth1,*, Juan P. Casas1 and Aroon D. Hingorani2

1 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
2 Centre for Clinical Pharmacology, University College London, UK

* Corresponding author: Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Tel: +44 20 7927 2296; fax: +44 20 7580 6897. E-mail address: liam.smeeth@lshtm.ac.uk

This editorial refers to ‘Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: results from 8 years of autopsies in 34 892 subjects’{dagger} by M. Majid et al., on page 1205

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The study by Madjid et al. is a valuable addition to the evidence supporting a role for infections in cardiovascular disease. Capitalizing on the very high rate of autopsies that are routinely performed in St Petersburg and the availability of high quality data about circulating levels of influenza infection, a clear association between influenza epidemics and increased rates of deaths from coronary heart disease was demonstrated. The association may not, of course, be causal. Ambient cold temperatures are likely to have been closely associated with levels of influenza, and could well have contributed to the effect on coronary death observed, particularly given the setting of northern Russia. However, the study by Madjid et al.1 does provide further support for a role of infection in triggering acute vascular events. A sharp . . . [Full Text of this Article]


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Related articles in EHJ:

Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: results from 8 years of autopsies in 34 892 subjects
Mohammad Madjid, Charles C. Miller, Vladimir V. Zarubaev, Ivan G. Marinich, Oleg I. Kiselev, Yury V. Lobzin, Alexander E. Filippov, and Samuel Ward Casscells, III
EHJ 2007 28: 1205-1210. [Abstract] [Full Text]