European Heart Journal Advance Access originally published online on August 22, 2007
European Heart Journal 2007 28(18):2179-2180; doi:10.1093/eurheartj/ehm170
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
D-dimers in atrial fibrillation: a further step in risk stratification of thrombo-embolism?
1 Department of Cardiology, Saint-Antoine University and Medical School, Assistance Publique-Hôpitaux de Paris, 184, rue du faubourg St-Antoine, 75571 Paris Cedex 12, France and
2 Université Pierre et Marie Curie, Paris, France
* Corresponding author. Tel: +33 1 49 28 28 86; fax: + 33 1 49 28 28 84. E-mail address: ariel.cohen@sat.aphp.fr
This editorial refers to Prediction of left atrial appendage thrombi in non-valvular atrial fibrillation by S. Habara et al., on page 2217
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The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.
| The first 10% of the full text of this article appears below. |
Plasma fibrin D-dimers (hereafter D-dimers) are generated when the endogenous fibrinolytic system degrades fibrin, as in venous thrombo-embolism (VTE) and they consist of two identical subunits derived from two fibrin molecules. Unlike fibrinogen degradation products, which are derived from fibrinogen and fibrin, D-dimers are a specific cross-linked fibrin derivative.1 Because 2–3% of plasma fibrinogen is degraded to fibrin, small amounts are detectable in the plasma of healthy individuals.1 D-dimer levels may be increased in any condition involving the formation and degradation of fibrin, such as VTE, pulmonary
D-dimers in atrial fibrillation
Markers of thrombo-embolism in atrial fibrillation
D-dimers and transeosophageal echocardiography-detected risk markers in atrial fibrillation
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Related articles in EHJ:
- Prediction of left atrial appendage thrombi in non-valvular atrial fibrillation
- Seiji Habara, Keigo Dote, Masaya Kato, Shota Sasaki, Kenji Goto, Hiroaki Takemoto, Daiji Hasegawa, and Osamu Matsuda
EHJ 2007 28: 2217-2222.[Abstract] [Full Text]