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The pattern of restenosis and vascular remodelling after cold-end adioactive stent implantation

I. P. Kay , A. J. Wardeh , K. Kozuma , G. Sianos , E. Regar , M. Knook , W. J. van der Giessen , A. Thury , J. M. R. Ligthart , V. M. A. Coen , P. C. Levendag , P. W. Serruys
DOI: http://dx.doi.org/10.1053/euhj.2000.2542 1311-1317 First published online: 1 August 2001

Abstract

Background Edge restenosis is a major problem after radioactive stenting. The cold-end stent has a radioactive mid-segment (15·9mm) and non-radioactive proximal and distal 5·7mm segments. Conceptually this may negate the impact of negative vascular remodelling at the edge of the radiation.

Method and Results ECG-gated intravascular ultrasound with three-dimensional reconstruction was performed post-stent implantation and at the 6-month follow-up to assess restenosis within the margins of the stent and at the stent edges in 16 patients. Angiographic restenosis was witnessed in four patients, all in the proximal in-stent position. By intravascular ultrasound in-stent neointimal hyperplasia, with a >50% stented cross-sectional area, was seen in eight patients. This was witnessed proximally (n=2), distally (n=2) and in both segments (n=4). Echolucent tissue, dubbed the ‘black hole’ was seen as a significant component of neointimal hyperplasia in six out of the eight cases of restenosis. Neointimal hyperplasia was inhibited in the area of radiation: Δ neointimal hyperplasia=3·72mm3(8·6%); in-stent at the edges of radiation proximally and distally Δ neointimal hyperplasia was 7·9mm3(19·0%) and 11·4mm3(25·6%), respectively (P=0·017). At the stent edges there was no significant change in lumen volume.

Conclusions Cold-end stenting results in increased neointimal hyperplasia in in-stent non-radioactive segments.

  • Stents, remodelling, radioisotopes, angioplasty, ultrasonics