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The gut microbiome as novel cardio-metabolic target: the time has come!

Sarah Vinjé , Erik Stroes , Max Nieuwdorp , Stan L. Hazen
DOI: http://dx.doi.org/10.1093/eurheartj/eht467 883-887 First published online: 11 November 2013

Abstract

Recent studies reveal a potential contribution of intestinal microbes in the expression of certain human cardio-metabolic diseases. The mechanisms through which intestinal microbiota and/or their metabolic products alter systemic homoeostasis and cardio-metabolic disease risks are just beginning to be dissected. Intervention studies in humans aiming to either selectively alter the composition of the intestinal microbiota or to pharmacologically manipulate the microbiota to influence production of their metabolites are crucial next steps. The intestinal microbiome represents a new potential therapeutic target for the treatment of cardio-metabolic diseases.

  • Gutmicrobiota
  • Vascular inflammation
  • Atherothrombosis
  • Insulin resistance
  • Obesity
  • TMAO
  • Therapy
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