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A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy

Benjamin Meder, Frank Rühle, Tanja Weis, Georg Homuth, Andreas Keller, Jennifer Franke, Barbara Peil, Justo Lorenzo Bermejo, Karen Frese, Andreas Huge, Anika Witten, Britta Vogel, Jan Haas, Uwe Völker, Florian Ernst, Alexander Teumer, Philipp Ehlermann, Christian Zugck, Frauke Friedrichs, Heyo Kroemer, Marcus Dörr, Wolfgang Hoffmann, Bernhard Maisch, Sabine Pankuweit, Volker Ruppert, Thomas Scheffold, Uwe Kühl, Hans-Peter Schultheiss, Reinhold Kreutz, Georg Ertl, Christiane Angermann, Philippe Charron, Eric Villard, Françoise Gary, Richard Isnard, Michel Komajda, Matthias Lutz, Thomas Meitinger, Moritz F. Sinner, H.-Erich Wichmann, Michael Krawczak, Boris Ivandic, Dieter Weichenhan, Goetz Gelbrich, Nour-Eddine El-Mokhtari, Stefan Schreiber, Stephan B. Felix, Gerd Hasenfuß, Arne Pfeufer, Norbert Hübner, Stefan Kääb, Eloisa Arbustini, Wolfgang Rottbauer, Norbert Frey, Monika Stoll, Hugo A. Katus
DOI: http://dx.doi.org/10.1093/eurheartj/eht251 1069-1077 First published online: 12 July 2013

Abstract

Aims Dilated cardiomyopathy (DCM) is one of the leading causes for cardiac transplantations and accounts for up to one-third of all heart failure cases. Since extrinsic and monogenic causes explain only a fraction of all cases, common genetic variants are suspected to contribute to the pathogenesis of DCM, its age of onset, and clinical progression. By a large-scale case-control genome-wide association study we aimed here to identify novel genetic risk loci for DCM.

Methods and results Applying a three-staged study design, we analysed more than 4100 DCM cases and 7600 controls. We identified and successfully replicated multiple single nucleotide polymorphism on chromosome 6p21. In the combined analysis, the most significant association signal was obtained for rs9262636 (P = 4.90 × 10−9) located in HCG22, which could again be replicated in an independent cohort. Taking advantage of expression quantitative trait loci (eQTL) as molecular phenotypes, we identified rs9262636 as an eQTL for several closely located genes encoding class I and class II major histocompatibility complex heavy chain receptors.

Conclusion The present study reveals a novel genetic susceptibility locus that clearly underlines the role of genetically driven, inflammatory processes in the pathogenesis of idiopathic DCM.

  • Dilated cardiomyopathy
  • DCM
  • Genome-wide association study
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