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Medial vascular calcification revisited: review and perspectives

Peter Lanzer, Manfred Boehm, Victor Sorribas, Marc Thiriet, Jan Janzen, Thomas Zeller, Cynthia St Hilaire, Catherine Shanahan
DOI: http://dx.doi.org/10.1093/eurheartj/ehu163 1515-1525 First published online: 16 April 2014

Abstract

Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.

  • Vascular calcifications
  • Mönckeberg's media sclerosis
  • Vascular molecular biology and genetics
  • Vascular function
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