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Treating hypertension in the very elderly—benefits, risks, and future directions, a focus on the hypertension in the very elderly trial

Ruth Peters, Nigel Beckett, Terry McCormack, Robert Fagard, Astrid Fletcher, Christopher Bulpitt
DOI: http://dx.doi.org/10.1093/eurheartj/eht464 1712-1718 First published online: 3 December 2013


Although the number of individuals reaching 80 who are considered to be healthy is increasing, the very elderly are likely to have long-term conditions, to report symptoms and/or be taking at least one regular medication. The impact of antihypertensive treatment has to be taken into account in this context. The treatment regimen in Hypertension in the Very Elderly Trial with a goal blood pressure of <150/80 mmHg has been shown to provide benefits in terms of a reduction in risk of total mortality, stroke, and cardiovascular events with potential benefits and no evidence of increased risk for fracture, dementia, depression, and quality-of-life outcomes. Questions remain as to the level of benefit that would be accrued in the frailer elderly and those at extreme age, for example, over 90.

  • Hypertension
  • Antihypertensives
  • Aged
  • Elderly
  • Benefit
  • Risk
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