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Non-pharmacological modulation of the autonomic tone to treat heart failure

Jagmeet P. Singh, Jagdesh Kandala, A. John Camm
DOI: http://dx.doi.org/10.1093/eurheartj/eht436 eht436 First published online: 29 October 2013


The autonomic nervous system has a significant role in the pathophysiology and progression of heart failure. The absence of any recent breakthrough advances in the medical therapy of heart failure has led to the evolution of innovative non-pharmacological interventions that can favourably modulate the cardiac autonomic tone. Several new therapeutic modalities that may act at different levels of the autonomic nervous system are being investigated for their role in the treatment of heart failure. The current review examines the role of renal denervation, vagal nerve stimulators, carotid baroreceptors, and spinal cord stimulators in the treatment of heart failure.

  • Autonomic nervous system
  • Sympathetic nervous system
  • Parasympathetic nervous system
  • Renal denervation
  • Vagal nerve stimulator
  • Carotid baroreceptor stimulation
  • Heart rate variability
  • Baroreflex sensitivity
  • Spinal cord stimulation
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