KasperGadsbøll, LailaStaerk, Emil LoldrupFosbøl, CarolineSindet-Pedersen, AnnaGundlund, Gregory Y.H.Lip, Gunnar HilmarGislason, Jonas BjerringOlesenEur Heart J(2017)ehw658DOI: http://dx.doi.org/10.1093/eurheartj/ehw658First published online: 21 January 2017 (8 pages)
Jose MariaOliver, PastoraGallego, Ana ElviraGonzalez, DiegoGarcia-Hamilton, PabloAvila, RaquelYotti, IgnacioFerreira, FranciscoFernandez-AvilesEur Heart J(2017)ehw590DOI: http://dx.doi.org/10.1093/eurheartj/ehw590First published online: 10 January 2017 (10 pages)
Martin F.Reiner, AlexanderBreitenstein, Erik W.Holy, MartinaGlanzmann, HeidiAmstalden, Simon F.Stämpfli, Nicole R.Bonetti, VolkmarFalk, StephanKeller, GianluigiSavarese, StefanoBenussi, FrancescoMaisano, Thomas F.Lüscher, Jürg H.Beer, JanSteffel, Giovanni G.CamiciEur Heart J(2017)ehw578DOI: http://dx.doi.org/10.1093/eurheartj/ehw578First published online: 8 January 2017 (4 pages)
Christina L.Fanola, Robert P.Giugliano, Christian T.Ruff, MarcoTrevisan, FrancescoNordio, Michele F.Mercuri, Elliott M.Antman, EugeneBraunwaldEur Heart J(2017)ehw565DOI: http://dx.doi.org/10.1093/eurheartj/ehw565First published online: 6 January 2017 (9 pages)
Donald M.Lyall, Carlos A.Celis-Morales, JanaAnderson, Jason M. R.Gill, Daniel F.Mackay, Andrew M.McIntosh, Daniel J.Smith, Ian J.Deary, NaveedSattar, Jill P.PellEur Heart J(2016)ehw528DOI: http://dx.doi.org/10.1093/eurheartj/ehw528First published online: 15 November 2016 (7 pages)
Azmil H.Abdul-Rahim, Ana-CristinaPerez, Rachael L.MacIsaac, Pardeep S.Jhund, Brian L.Claggett, Peter E.Carson, MichelKomajda, Robert S.McKelvie, Michael R.Zile, KarlSwedberg, SalimYusuf, Marc A.Pfeffer, Scott D.Solomon, Gregory Y.H.Lip, Kennedy R.Lees, John J.V.McMurrayEur Heart J(2016)ehw509DOI: http://dx.doi.org/10.1093/eurheartj/ehw509First published online: 13 November 2016 (9 pages)
MarcoValgimigli, FrancescoCosta, YuliyaLokhnygina, Robert M.Clare, LarsWallentin, David J.Moliterno, Paul W.Armstrong, Harvey D.White, ClaesHeld, Philip E.Aylward, FransVan de Werf, Robert A.Harrington, Kenneth W.Mahaffey, PierluigiTricociEur Heart J(2016)ehw525DOI: http://dx.doi.org/10.1093/eurheartj/ehw525First published online: 13 November 2016 (9 pages)
Philippe Jvan Rosendael, VasileiosKamperidis, William K.F.Kong, Alexander Rvan Rosendael, Frankvan der Kley, NinaAjmone Marsan, VictoriaDelgado, Jeroen JBaxEur Heart J(2016)ehw499DOI: http://dx.doi.org/10.1093/eurheartj/ehw499First published online: 2 November 2016 (10 pages)
FilippoCrea, C. NoelBairey Merz, John F.Beltrame, Juan CarlosKaski, HisaoOgawa, PeterOng, UdoSechtem, HiroakiShimokawa, Paolo G.CamiciEur Heart J(2016)ehw461DOI: http://dx.doi.org/10.1093/eurheartj/ehw461First published online: 23 October 2016 (5 pages)
LailaStaerk, Emil LoldrupFosbøl, Gregory Y.H.Lip, MortenLamberts, Anders NissenBonde, ChristianTorp-Pedersen, BriceOzenne, Thomas AlexanderGerds, Gunnar HilmarGislason, Jonas BjerringOlesenEur Heart J(2016)ehw496DOI: http://dx.doi.org/10.1093/eurheartj/ehw496First published online: 14 October 2016 (9 pages)
Thomas M.MacDonald, Chris J.Hawkey, IanFord, John J.V.McMurray, James M.Scheiman, JesperHallas, EvelynFindlay, Diederick E.Grobbee, F.D. RichardHobbs, Stuart H.Ralston, David M.Reid, Matthew R.Walters, JohnWebster, FrankRuschitzka, SirLewis D.Ritchie, SusanaPerez-Gutthann, EugeneConnolly, NicolaGreenlaw, AdamWilson, LiWei, Isla S.MackenzieEur Heart J(2016)ehw387DOI: http://dx.doi.org/10.1093/eurheartj/ehw387First published online: 4 October 2016 (9 pages)
Exosomes secreted by cardiosphere-derived cells (CDCs) were studied as a therapy for myocardial infarction (MI). In two different porcine models, exosomes from CDCs limited injury when given acutely and halted adverse remodelling when given in convalescent MI. Both models showed decreased scarring and improved function with intramyocardial delivery of exosomes. Cardiosphere-derived cell-secreted exosomes are a promising cell-free therapy for MI.
ThomasMünzel, MetteSørensen, TommasoGori, Frank P.Schmidt, XiaoquanRao, Frank R.Brook, Lung ChiChen, Robert D.Brook, SanjayRajagopalanEur Heart J(2016)ehw294DOI: http://dx.doi.org/10.1093/eurheartj/ehw294First published online: 26 July 2016 (8 pages)
Andrew PaulDeFilippis, RebekahYoung, John W.McEvoy, Erin D.Michos, VeitSandfort, Richard A.Kronmal, Robyn L.McClelland, Michael J.BlahaEur Heart J(2016)ehw301DOI: http://dx.doi.org/10.1093/eurheartj/ehw301First published online: 19 July 2016 (11 pages)
To protect patients after MI by preserving cardiac function, the development of novel therapeutics is essential. In the current study, we assessed the effect of interference with NLRP3-inflammasome signalling on infarct size and cardiac function in a porcine MI model. For the first time, we show that cardiac function is preserved and infarct size is reduced by attenuating inflammation through NLRP3-inflammasome inhibition in a large animal MI model, making interference with this specific signalling pathway a promising target in MI patients.
Carlos A.Celis-Morales, Donald M.Lyall, JanaAnderson, StamatinaIliodromiti, YuFan, Uduakobong E.Ntuk, Daniel F.Mackay, Jill P.Pell, NaveedSattar, Jason M.R.GillEur Heart J(2016)ehw249DOI: http://dx.doi.org/10.1093/eurheartj/ehw249First published online: 6 July 2016 (7 pages)
Stratification for coronary events among patients with coronary artery disease is of considerable interest because of the potential to guide secondary preventive therapies. Our study proofs, that circulating miRNAs have the potential to improve risk stratification for secondary clinical events. In the future, these findings may result in risk stratification tools based on the prognostic value of miRNAs.
MercedesOrtiz, AlfonsoMartín, FernandoArribas, BlancaColl-Vinent, Carmendel Arco, RafaelPeinado, JesúsAlmendral
on behalf ofon Behalf of the PROCAMIO Study InvestigatorsEur Heart J(2016)ehw230DOI: http://dx.doi.org/10.1093/eurheartj/ehw230First published online: 28 June 2016 (8 pages)
Cardiomyocytes (CMs) generated from human induced pluripotent stem cells are an evolving platform to understand molecular disease mechanism and evaluate cardiovascular drugs. A major limitation of this system is that they represent a heterogeneous mix of ventricular-, atrial-, and nodal-like CMs. By expressing a voltage-sensitive fluorescent protein under the control of lineage-specific promoters, we developed a convenient system allowing high-throughput subtype-specific optical action potential (AP) imaging in these cells. This enables not only quantification of electrical phenotypes in patient-specific CMs but also subtype-specific investigation of drug effects, which may aid both drug development and safety pharmacology in the cardiovascular field.